Sarraj Amrou, Yoshimura Shinichi, Thomalla Götz, Huo Xiaochuan, Arquizan Caroline, Yoo Albert J, Morimoto Takeshi, Bendszus Martin, Lapergue Bertrand, Nguyen Thanh N, Campbell Bruce C V, Costalat Vincent, Fiehler Jens, Jovin Tudor G, Zaidat Osama O, Miao Zhongrong
Neurology, University Hospitals Cleveland Medical Center, OH (A.S.).
Neurology, Case Western Reserve University School of Medicine, Cleveland, OH (A.S.).
Stroke. 2025 Jul;56(7):1917-1927. doi: 10.1161/STROKEAHA.125.050402. Epub 2025 May 20.
Recently, 6 randomized trials evaluated the efficacy and safety of endovascular thrombectomy in patients with large core stroke. This review examines the differences in clinical and imaging eligibility and their impact on the interpretation of evidence and potential neuroimaging workflow. Pending results of a planned patient-level meta-analysis, it also evaluates clinical outcomes and thrombectomy treatment effect across those trials, overall and within selected clinical and imaging subgroups most relevant to clinical practice. Additionally, the implications of extending thrombectomy eligibility to patients with large core stroke on stroke systems of care and societal benefits are discussed.
最近，6项随机试验评估了血管内血栓切除术对大面积梗死核心的中风患者的疗效和安全性。本综述探讨了临床和影像学纳入标准的差异及其对证据解读和潜在神经影像工作流程的影响。在计划中的患者水平荟萃分析结果出来之前，本综述还评估了这些试验中的临床结局和血栓切除术治疗效果，包括总体情况以及在与临床实践最相关的选定临床和影像学亚组中的情况。此外，还讨论了将血栓切除术的适用范围扩大到大面积梗死核心的中风患者对中风护理系统和社会效益的影响。
N Engl J Med. 2023-4-6
Cochrane Database Syst Rev. 2022-7-20
J Stroke Cerebrovasc Dis. 2017-8
Acta Neurochir (Wien). 2024-4-26
Cochrane Database Syst Rev. 2017-5-26
Neurol Ther. 2025-8-13
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