甲硫氨酸脑啡肽可抑制应激诱导的大鼠脑区去甲肾上腺素周转率增加。
Methionine-enkephalin inhibits stress-induced increases in noradrenaline turnover in brain regions of rats.
作者信息
Tanaka M, Tsuda A, Ida Y, Ushijima I, Tsujimaru S, Nagasaki N
出版信息
Jpn J Pharmacol. 1985 Jan;37(1):117-9. doi: 10.1254/jjp.37.117.
PMID:4039384
Abstract
Met-Enkephalin injected i.c.v. attenuated stress-induced increases in levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate, the major metabolite of brain noradrenaline, in the hypothalamus, amygdala, hippocampus, thalamus, midbrain and LC region in rats. The data suggest that Met-enkephalin acts to attenuate stress-induced increases in noradrenaline turnover in these brain regions in rats.
摘要
脑室内注射甲硫氨酸脑啡肽可减弱应激诱导的大鼠下丘脑、杏仁核、海马体、丘脑、中脑和蓝斑区域中3-甲氧基-4-羟基苯乙二醇硫酸盐（脑去甲肾上腺素的主要代谢产物）水平的升高。数据表明，甲硫氨酸脑啡肽的作用是减弱应激诱导的大鼠这些脑区去甲肾上腺素周转率的升高。
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