人类免疫缺陷病毒（HIV）感染状况会改变乳腺癌女性患者的免疫细胞浸润及激活情况。
HIV status alters immune cell infiltration and activation profile in women with breast cancer.
作者信息
Bauer Marcus, Santos Pablo, Wilfer Andreas, van den Berg Eunice, Zietsman Annelle, Vetter Martina, Kaufhold Sandy, Wickenhauser Claudia, Dos-Santos-Silva Isabel, Chen Wenlong Carl, Cubasch Herbert, Murugan Nivashini, McCormack Valerie, Joffe Maureen, Seliger Barbara, Kantelhardt Eva
机构信息
Institute of Pathology, University Hospital Halle, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Global and Planetary Health Working Group, Institute of Medical Epidemiology, Biometrics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
出版信息
Nat Commun. 2025 May 20;16(1):4699. doi: 10.1038/s41467-025-59408-8.
The breast cancer (BC)-related mortality is higher and the immunity is altered in women living with HIV (WLWH) compared to HIV-negative women. Therefore, tumor samples of 296 black BC patients from South Africa and Namibia with known age, HIV status, tumor stage, hormone receptor and HER2 status and overall survival (OS) are analyzed for components of the tumor microenvironment (TME). WLWH (n = 117), either with suppressed viral activity (HR = 1.25) or with immune suppression (HR = 2.04), have a shorter OS. HIV status is associated with increased numbers of CD8 T cells in the TME compared to HIV-negative patients; no correlation is found with CD4 T cell numbers in the blood. Moreover, an increased expression of CD276/B7-H3 and a more pronounced IFN-γ signaling in the tumors are found in WLWH, independent of age, stage, and BC subtypes. In conclusion, altered T cell composition and CD276 expression in WLWH may contribute to inferior survival and can be used for targeted treatment.
与HIV阴性女性相比，感染HIV的女性（WLWH）的乳腺癌（BC）相关死亡率更高，免疫力也发生了改变。因此，对来自南非和纳米比亚的296名已知年龄、HIV状态、肿瘤分期、激素受体和HER2状态以及总生存期（OS）的黑人BC患者的肿瘤样本进行了肿瘤微环境（TME）成分分析。WLWH（n = 117），无论是病毒活性受到抑制（HR = 1.25）还是存在免疫抑制（HR = 2.04），其OS都较短。与HIV阴性患者相比，HIV状态与TME中CD8 T细胞数量增加有关；与血液中的CD4 T细胞数量无相关性。此外，在WLWH中发现肿瘤中CD276/B7-H3的表达增加以及更明显的IFN-γ信号传导，这与年龄、分期和BC亚型无关。总之，WLWH中T细胞组成和CD276表达的改变可能导致生存期较差，并可用于靶向治疗。
Zotero 插件