抗微生物药物耐药性的代价：抗菌药物耐药性
The price of WAR: AMR.
作者信息
Rojas Laura J, Lemonovich Tracy L, Marshall Steven H, Hirschfeld Adam, Perez Federico, Bonomo Robert A
机构信息
Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, OH, USA.
出版信息
JAC Antimicrob Resist. 2025 May 20;7(3):dlaf083. doi: 10.1093/jacamr/dlaf083. eCollection 2025 Jun.
BACKGROUND
The ongoing conflict in Ukraine has exacerbated the risk of MDR bacterial infections in war-injured patients.
METHODS
We present the case of a Ukrainian soldier who sustained a traumatic explosive injury to the bilateral lower extremities, underwent surgery and subsequently experienced an infection with a carbapenem-resistant . The isolate was subject to genomic WGS.
RESULTS
This case study describes the successful management of a traumatic injury in a Ukrainian soldier infected with a carbapenem-resistant isolated from surgical wounds. WGS revealed a hypervirulent ST147 strain carrying multiple resistance and virulence factors, including . Treatment with ceftazidime/avibactam and aztreonam was effective.
CONCLUSIONS
Ceftazidime/avibactam and aztreonam is highlighted as a promising regimen for MDR infections in conflict zones.
背景
乌克兰持续的冲突加剧了战争受伤患者发生耐多药细菌感染的风险。
方法
我们报告了一名乌克兰士兵的病例，该士兵双下肢遭受创伤性爆炸伤，接受了手术，随后感染了耐碳青霉烯类细菌。对分离株进行了全基因组测序（WGS）。
结果
本病例研究描述了一名感染了从手术伤口分离出的耐碳青霉烯类细菌的乌克兰士兵创伤性损伤的成功治疗。全基因组测序显示该菌株为高毒力ST147菌株，携带多种耐药和毒力因子，包括……。使用头孢他啶/阿维巴坦和氨曲南治疗有效。
结论
头孢他啶/阿维巴坦和氨曲南被强调为冲突地区耐多药感染的一种有前景的治疗方案。
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