吗啡和可乐定口服自我给药：对吗啡依赖或戒断大鼠的一项研究。

Morphine and clonidine oral self-administration: a study in morphine dependent or abstinent rats.

作者信息

Gaiardi M, Bartoletti M, Bacchi A, Gubellini C, Babbini M

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(2):143-51. doi: 10.1016/0278-5846(85)90076-4.

Abstract

The ability of morphine and of clonidine to support self-administration has been evaluated in morphine dependent or abstinent rats, using an orally reinforced operant technique (F.R. 20). It was found that: Morphine drinking can function as a reinforcer of an operant response both in dependent and abstinent rats. The bitter taste of morphine becomes a secondary reinforcer for rats usually working for the alkaloid. Clonidine supports oral self-administration in morphine abstinent, but not in morphine dependent rats. The data are in line with clinical findings and give a further evidence that oral self administration in rats can be an useful model for the analysis of drug dependence.

摘要

使用口服强化操作性技术（固定比率20），已在吗啡依赖或戒断的大鼠中评估了吗啡和可乐定支持自我给药的能力。结果发现：吗啡饮水在依赖和戒断的大鼠中均可作为操作性反应的强化物。吗啡的苦味成为通常为该生物碱而工作的大鼠的二级强化物。可乐定支持吗啡戒断大鼠的口服自我给药，但不支持吗啡依赖大鼠。这些数据与临床发现一致，并进一步证明大鼠的口服自我给药可作为分析药物依赖的有用模型。