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搏动性耳鸣患者乙状窦憩室的血管内治疗

Endovascular treatment of sigmoid Sinus diverticulum in patients with pulsatile tinnitus.

作者信息

Abdalkader Mohamad, Klein Piers, Setty Bindu, Andreu Arasa Vanesa Carlota, Farris Chad, Mian Asim, Bedi Harprit, Peeler Crandall, Aliphas Avner, Weber Peter, Hu Wei, Sakai Osamu, Nguyen Thanh N

机构信息

Department of Radiology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

Department of Ophthalmology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

出版信息

Interv Neuroradiol. 2025 May 21:15910199251342397. doi: 10.1177/15910199251342397.

Abstract

BackgroundSigmoid sinus diverticula (SSD) are increasingly recognized among the most common causes of pulsatile tinnitus (PT). However, questions remain regarding their etiopathogenesis and optimal management. This study aims to review and compare management strategies and outcomes of SSD treated endovascularly in patients with PT.MethodsWe retrospectively reviewed all patients with refractory PT who were found to have SSD and were treated endovascularly between September 2020 and January 2024. Clinical features, radiological findings, and endovascular strategies were analyzed. Outcomes were evaluated at 24 hours, 3 months, and 1 year.ResultsA total of 26 SSDs were found in 23 patients. Diverticula were categorized as saccular in 76.9% (20/26) of cases and as fusiform in 23.1% (6/26) of cases. Their median dimensions were 5.1 mm [IQR 3.8-6.7 mm] in the transverse axis. Transverse sinus stenosis was present in all cases (26/26) with a median pre-procedural pressure gradient of 8 mmHg ([4-11 mmHg];  = 23). Idiopathic intracranial hypertension was present in 65.4% (17/26) of cases. Ipsilateral sigmoid wall dehiscence was present in 84.6% (22/26) of cases. Stenting alone was performed in 14 cases (53.8%), stent-assisted coiling in 9 cases (34.6), and coiling alone was performed in 3 cases (11.5%). The primary outcome of treatment success, defined as complete resolution of PT at 3 months, occurred in 88.5% (23/26) of cases. Partial resolution of PT at 3 months occurred in an additional 11.5% (3/26) of cases. There was no difference in outcome between the different endovascular treatments at any time point (24 hours  = 0.58; 3 months  = 1.00; 1 year  = 1).ConclusionEndovascular treatment is safe and effective in resolving PT in patients with sigmoid sinus diverticulum. Stenting alone was as effective as stent-assisted coiling, indicating that direct treatment of the diverticulum may not be necessary as long as the associated stenosis is addressed. Further studies are needed to validate these findings and to refine the therapeutic options in PT patients with venous sinus anomalies.

摘要

背景

乙状窦憩室(SSD)日益被认为是搏动性耳鸣(PT)最常见的病因之一。然而,关于其发病机制和最佳治疗方法仍存在疑问。本研究旨在回顾和比较经血管内治疗PT患者的SSD的治疗策略和结果。

方法

我们回顾性分析了2020年9月至2024年1月期间所有经血管内治疗的难治性PT且发现患有SSD的患者。分析临床特征、影像学表现和血管内治疗策略。在24小时、3个月和1年时评估治疗结果。

结果

23例患者共发现26个SSD。憩室在76.9%(20/26)的病例中被分类为囊状,在23.1%(6/26)的病例中被分类为梭形。其横轴的中位尺寸为5.1 mm[四分位间距3.8 - 6.7 mm]。所有病例(26/26)均存在横窦狭窄,术前中位压力梯度为8 mmHg([4 - 11 mmHg];n = 23)。65.4%(17/26)的病例存在特发性颅内高压。84.6%(22/26)的病例存在同侧乙状窦壁裂开。14例(53.8%)仅行支架置入术,9例(34.6%)行支架辅助弹簧圈栓塞术,3例(11.5%)仅行弹簧圈栓塞术。治疗成功的主要结局定义为3个月时PT完全缓解,88.5%(23/26)的病例出现该结局。另外11.5%(3/26)的病例在3个月时PT部分缓解。在任何时间点,不同血管内治疗方法的结局均无差异(24小时:P = 0.58;3个月:P = 1.00;1年:P = 1)。

结论

血管内治疗在解决乙状窦憩室患者的PT方面是安全有效的。单纯支架置入术与支架辅助弹簧圈栓塞术效果相同,表明只要解决相关狭窄,可能无需直接治疗憩室。需要进一步研究来验证这些发现并完善PT合并静脉窦异常患者的治疗选择。

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Interv Neuroradiol. 2024 Sep 19:15910199241272645. doi: 10.1177/15910199241272645.
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