用于评估印度儿童和青少年骨骼健康的月球iDXA参考数据：一项横断面研究。
Reference Data for Lunar iDXA for the Assessment of Bone Health in Indian Children and Youth: A Cross-Sectional Study.
作者信息
Khadilkar Anuradha, Oza Chirantap, Sanwalka Neha, Kajale Neha, Patwardhan Vivek, Ladkat Dipali, Ireland Alex, Padidela Raja, Khadilkar Vaman
机构信息
Department of Growth and Pediatric Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Lower Basement, Block V Jehangir Hospital, 32, Sassoon Road, Pune, Maharashtra, 411001, India.
Interdisciplinary School of Health Sciences, Savitribai Phule University, Pune, India.
出版信息
Indian Pediatr. 2025 Aug;62(8):578-585. doi: 10.1007/s13312-025-00091-9. Epub 2025 May 22.
OBJECTIVE
Dual energy x-ray absorptiometry (DXA) is the commonest bone densitometry technique in children. As no pediatric reference database for Indian children using a narrow fan beam densitometer is available, the aim of the study was to provide sex- and age-specific reference percentile curves for the assessment of bone health using the Lunar iDXA in 1-19-year-old Indian children.
METHODS
A cross-sectional study was carried out between November 2017 and July 2022 involving 1247 (607 girls) healthy children from Pune, India. The bone mineral content [BMC (g)], bone area [BA (cm)], and bone mineral density [BMD (g/cm)] were measured using the GE-Lunar iDXA narrow-angle fan beam scanner. Reference percentile curves were generated for total body BMC (TBBMC), total body BA (TBBA), lumbar spine bone mineral apparent density [BMAD (g/cm)], and left femoral neck BMAD. Additionally, we provided percentile curves for TBBA relative to height, TBBMC relative to TBBA, lean body mass (LBM) relative to height, and TBBMC relative to LBM.
RESULTS
Mean (SD) bone parameters were expressed by age groups for boys and girls separately. The average annual age-related increase in TBBMD, lumbar spine BMD, and femoral neck BMD was 6.3, 7.2, and 4.5%, respectively, across different age groups. The median TBBA and TBBMC for height were higher in boys than girls by 14.7 and 24.9%, respectively. Similarly, the median TBBMC for LBM was 36.8% higher in boys as compared to girls.
CONCLUSION
The study reports reference curves for DXA parameters (narrow fan beam) for Indian children and youth.
目的
双能X线吸收法（DXA）是儿童中最常用的骨密度测量技术。由于没有针对使用窄扇形束密度计的印度儿童的儿科参考数据库，本研究的目的是提供1至19岁印度儿童使用Lunar iDXA评估骨骼健康的性别和年龄特异性参考百分位数曲线。
方法
在2017年11月至2022年7月期间进行了一项横断面研究，涉及来自印度浦那的1247名（607名女孩）健康儿童。使用GE-Lunar iDXA窄角扇形束扫描仪测量骨矿物质含量[BMC（克）]、骨面积[BA（平方厘米）]和骨矿物质密度[BMD（克/平方厘米）]。生成了全身BMC（TBBMC）、全身BA（TBBA）、腰椎骨矿物质表观密度[BMAD（克/平方厘米）]和左股骨颈BMAD的参考百分位数曲线。此外，我们还提供了TBBA相对于身高、TBBMC相对于TBBA、瘦体重（LBM）相对于身高以及TBBMC相对于LBM的百分位数曲线。
结果
分别按年龄组列出了男孩和女孩的平均（标准差）骨参数。在不同年龄组中，TBBMD、腰椎BMD和股骨颈BMD的平均每年年龄相关增加分别为6.3%、7.2%和4.5%。男孩身高对应的TBBA和TBBMC中位数分别比女孩高14.7%和24.9%。同样，男孩LBM对应的TBBMC中位数比女孩高36.8%。
结论
本研究报告了印度儿童和青少年DXA参数（窄扇形束）的参考曲线。
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