Liu Haobiao, Xiang Rongqi, Liu Chenyue, Chen Zhuohang, Shi Yuhang, Liu Yiting, Liu Yan
Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Front Endocrinol (Lausanne). 2025 May 8;16:1535509. doi: 10.3389/fendo.2025.1535509. eCollection 2025.
The cardiometabolic index (CMI) serves as a comprehensive metric for evaluating cardiometabolic health, and is correlated with several health outcomes. However, research examining the relationship between CMI and bone mineral density (BMD), particularly in adolescent populations, remains limited and warrants further investigation.
The weighted multiple linear regression analysis was conducted to elucidate the association between CMI and BMD.
Our study ultimately included 1,514 participants. After adjusting for pertinent covariates, we observed that per-unit increases in the CMI corresponded with reductions in BMD by 0.052 g/cm for femoral neck (=-0.052, 95% CI: -0.087 to -0.018) and 0.048 g/cm for lumbar spine (L1-L4) (=-0.048, 95% CI: -0.085 to -0.011). In quartile analyses, individuals in the highest quartile displayed significantly reduced BMD at the femoral neck (=-0.036, 95% CI: -0.064 to -0.007) and lumbar spine (L1-L4) (=-0.041, 95% CI: -0.070 to -0.011) compared to those in the lowest quartile (<0.05). No statistical significance was detected between CMI and BMD at the total femur, trochanter, and intertrochanter sites. Furthermore, stratified analyses indicated no significant interactions involving age, sex, or race in relation to CMI and BMD.
In the adolescent population, CMI is inversely related to BMD. These findings highlight a potential link between cardiometabolic health and bone health. Future longitudinal investigations are warranted to determine causal relationships and underlying mechanisms.
心脏代谢指数（CMI）是评估心脏代谢健康的综合指标，与多种健康结局相关。然而，研究CMI与骨密度（BMD）之间关系的研究，尤其是在青少年人群中，仍然有限，值得进一步研究。
进行加权多元线性回归分析以阐明CMI与BMD之间的关联。
我们的研究最终纳入了1514名参与者。在调整相关协变量后，我们观察到CMI每增加一个单位，股骨颈骨密度降低0.052g/cm（β=-0.052，95%CI：-0.087至-0.018），腰椎（L1-L4）骨密度降低0.048g/cm（β=-0.048，95%CI：-0.085至-0.011）。在四分位数分析中，与最低四分位数的个体相比，最高四分位数的个体在股骨颈（β=-0.036，95%CI：-0.064至-0.007）和腰椎（L1-L4）（β=-0.041，95%CI：-0.070至-0.011）处的骨密度显著降低（P<0.05）。在股骨全长、大转子和转子间部位，未检测到CMI与BMD之间的统计学显著差异。此外，分层分析表明，在CMI与BMD的关系中，年龄、性别或种族之间不存在显著的交互作用。
在青少年人群中，CMI与BMD呈负相关。这些发现凸显了心脏代谢健康与骨骼健康之间的潜在联系。未来有必要进行纵向研究以确定因果关系和潜在机制。
