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Long non-coding RNA TMEM51-AS1 inhibits colorectal cancer progression.

作者信息

Wu Dongping, Xia Qing, Su Xinming, Mao Yunan, Mao Jiwei, Ding Qiannan, Liu Jianjiang, Zhong Wangyan, Zhang Xiaoyu, Li Hanbing, Duan Shiwei

机构信息

Department of Radiation Oncology, Shaoxing People's Hospital, Shaoxing, 312000, Zhejiang, China.

College of Pharmacy, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, China.

出版信息

Discov Oncol. 2025 May 23;16(1):878. doi: 10.1007/s12672-025-02676-z.

DOI:10.1007/s12672-025-02676-z
PMID:40407985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12102048/
Abstract

Colorectal cancer (CRC) is the third most common cause of death worldwide and has high mortality and a poor prognosis. Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides that play roles in cancer through multiple mechanisms. TMEM51-AS1 is a newly discovered 40,650 bp lncRNA. Our results showed that TMEM51-AS1 expression was significantly downregulated in CRC tissues (fold change = 0.74, P < 0.0001). This finding was confirmed in 20 pairs of CRC carcinoma and paracancerous tissues (fold change = 0.5, P < 0.001). Additionally, TMEM51-AS1 expression was found to be significantly reduced in CRC cell lines compared to normal human intestinal epithelial cells (P < 0.001). Bioinformatic analysis revealed that TMEM51-AS1 expression was associated with immune escape, RNA methylation, and DNA damage and repair. TMEM51-AS1 may also activate energy metabolism pathways to participate in cancer development. Drug sensitivity analysis confirmed that several drugs are more effective in CRC patients with high expression of TMEM51-AS1. In conclusion, our study demonstrates that TMEM51-AS1 can suppress the progression of CRC.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/7050a33d2d6d/12672_2025_2676_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/c07d9999c598/12672_2025_2676_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/f910d15705d1/12672_2025_2676_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/5084295789b5/12672_2025_2676_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/279e9c642ef7/12672_2025_2676_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/7050a33d2d6d/12672_2025_2676_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/c07d9999c598/12672_2025_2676_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/f910d15705d1/12672_2025_2676_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/5084295789b5/12672_2025_2676_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/279e9c642ef7/12672_2025_2676_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/12102048/7050a33d2d6d/12672_2025_2676_Fig5_HTML.jpg

相似文献

[1]
Long non-coding RNA TMEM51-AS1 inhibits colorectal cancer progression.

Discov Oncol. 2025-5-23

[2]
lncRNA TMEM51-AS1 and RUSC1-AS1 function as ceRNAs for induction of laryngeal squamous cell carcinoma and prediction of prognosis.

PeerJ. 2019-9-10

[3]
LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2.

Mol Cancer. 2019-9-6

[4]
Long non-coding RNA DCST1-AS1/hsa-miR-582-5p/HMGB1 axis regulates colorectal cancer progression.

Bioengineered. 2022-1

[5]
Long noncoding RNA HNF1A-AS1 indicates a poor prognosis of colorectal cancer and promotes carcinogenesis via activation of the Wnt/β-catenin signaling pathway.

Biomed Pharmacother. 2017-11-6

[6]
Decreased expression of LncRNA SLC25A25-AS1 promotes proliferation, chemoresistance, and EMT in colorectal cancer cells.

Tumour Biol. 2016-10

[7]
Long non-coding RNA FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer.

Cell Prolif. 2017-2

[8]
Long non-coding RNA MCF2L-AS1 promotes the aggressiveness of colorectal cancer by sponging miR-874-3p and thereby up-regulating CCNE1.

J Gene Med. 2021-1

[9]
Long non-coding RNA ZNFX1-AS1 promotes the tumor progression and metastasis of colorectal cancer by acting as a competing endogenous RNA of miR-144 to regulate EZH2 expression.

Cell Death Dis. 2019-2-15

[10]
Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer.

Clin Epigenetics. 2022-10-31

本文引用的文献

[1]
Targeting and engineering long non-coding RNAs for cancer therapy.

Nat Rev Genet. 2024-8

[2]
LncRNA Malat1 suppresses pyroptosis and T cell-mediated killing of incipient metastatic cells.

Nat Cancer. 2024-2

[3]
Personalizing adjuvant therapy for patients with colorectal cancer.

Nat Rev Clin Oncol. 2024-1

[4]
Amplifying gene expression with RNA-targeted therapeutics.

Nat Rev Drug Discov. 2023-7

[5]
N-methyladenosine modification in cancer biology: Current status and future perspectives.

Comput Struct Biotechnol J. 2022-11-25

[6]
Hepatic stellate cell-released CXCL1 aggravates HCC malignant behaviors through the MIR4435-2HG/miR-506-3p/TGFB1 axis.

Cancer Sci. 2023-2

[7]
Initial Impact of National CRC Screening on Incidence and Advanced Colorectal Cancer.

Clin Gastroenterol Hepatol. 2023-3

[8]
Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance.

Cell Death Discov. 2022-9-13

[9]
Functional Versatility of the Human 2-Oxoadipate Dehydrogenase in the L-Lysine Degradation Pathway toward Its Non-Cognate Substrate 2-Oxopimelic Acid.

Int J Mol Sci. 2022-7-26

[10]
Preliminary study on the role and mechanism of KIRREL3 in the development of esophageal squamous cell carcinoma.

Pathol Res Pract. 2022-9

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