血管加压素不会增强记忆过程：一项对人类双胞胎的研究。

Vasopressin does not enhance memory processes: a study in human twins.

作者信息

Fehm-Wolfsdorf G, Born J, Elbert T, Voigt K H, Fehm H L

出版信息

Peptides. 1985 Mar-Apr;6(2):297-300. doi: 10.1016/0196-9781(85)90055-5.

Abstract

Behavioral effects of lysin-vasopressin (LVP) were investigated applying two paradigms from human experimental psychology. The first task was designed to simulate amnesic symptoms in normals. The second task addressed the emotional value of the items to be processed. Additionally, EEG recordings were used as indicators of the central nervous system effectiveness of LVP. Blood pressure and heart rate measured peripheral arousal. The co-twin control method was employed to increase experimental power. Contrary to the prediction of the vasopressin memory hypothesis none of the specific memory parameters was improved by LVP treatment. Changes in the electrical activity of the brain, but not in blood pressure and heart rate indicated central nervous system actions of LVP. However, interpretation of LVP effects in terms of memory processing seems not to be justified.

摘要

应用人类实验心理学的两种范式，研究了赖氨酸加压素（LVP）的行为效应。第一项任务旨在模拟正常人的失忆症状。第二项任务涉及待处理项目的情感价值。此外，脑电图记录被用作LVP对中枢神经系统有效性的指标。血压和心率测量外周唤醒。采用同卵双胞胎对照方法来提高实验效能。与加压素记忆假说的预测相反，LVP治疗并未改善任何特定的记忆参数。大脑电活动的变化表明了LVP对中枢神经系统的作用，但血压和心率没有变化。然而，从记忆处理的角度来解释LVP的效应似乎并不合理。