Maj J, Chojnacka-Wójcik E, Lewandowska A, Tatarczyńska E, Wiczyńska B
Pol J Pharmacol Pharm. 1985 Jan-Feb;37(1):47-56.
Carbamazepine (CBZ) was studied in mice and rats with regard to its antidepressant activity. CBZ did not counteract hypothermia and ptosis induced by reserpine, hypothermia evoked by apomorphine, or sedation and hypothermia induced by clonidine. CBZ shortened the immobility time in the behavioral despair test in rats (but not in mice). It attenuated hyperactivity evoked by d-amphetamine, not affecting stereotypy induced by that drug. CBZ inhibited head twitches evoked by 5-HTP, as well as the hind limb flexor reflex of the spinal rat, having no effect on its stimulation by noradrenaline and 5-hydroxytryptamine agonists. CBZ administered repeatedly did not enhance clonidine aggressiveness or d-amphetamine locomotor hyperactivity, acting differently than many antidepressant drugs. The obtained results indicate that CBZ is not similar in its action to typical and many atypical antidepressants.
对小鼠和大鼠进行了卡马西平（CBZ）抗抑郁活性的研究。卡马西平不能对抗利血平引起的体温过低和眼睑下垂、阿扑吗啡诱发的体温过低，或可乐定引起的镇静和体温过低。卡马西平缩短了大鼠行为绝望试验中的不动时间（但对小鼠无效）。它减弱了右旋苯丙胺引起的多动，但不影响该药物诱发的刻板行为。卡马西平抑制了5-羟色氨酸诱发的头部抽搐以及脊髓大鼠的后肢屈肌反射，对去甲肾上腺素和5-羟色胺激动剂对其的刺激没有影响。反复给予卡马西平不会增强可乐定的攻击性或右旋苯丙胺的运动性多动，其作用与许多抗抑郁药物不同。所得结果表明，卡马西平的作用与典型和许多非典型抗抑郁药物不同。
