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经卵圆孔未闭处移动的广泛双房血栓:快速诊断与处理——病例报告

Extensive biatrial thrombus in transit across a patent foramen ovale: prompt diagnosis and management-a case report.

作者信息

Mehrpooya Maryam, Faramarzpour Maryam, Rahmanian Mehrzad, Fallahtafti Parisa, Eftekhari Mohammad Reza

机构信息

Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Department of Cardiac Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

BMC Cardiovasc Disord. 2025 May 23;25(1):392. doi: 10.1186/s12872-025-04798-2.

DOI:10.1186/s12872-025-04798-2
PMID:40410674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12103051/
Abstract

BACKGROUND

Thrombus in transit (TIT), a rare and life-threatening condition, poses risks of pulmonary and paradoxical embolism which needs prompt diagnosis. Our case report highlights the significance of utilizing advanced imaging techniques for accurate and timely diagnosis of TIT and the potential life-saving role of surgical thrombectomy. This case report discusses a rare instance of biatrial thrombus associated with venous thromboembolism (VTE) and patent foramen ovale (PFO). A 66-year-old female with multiple comorbidities presented with dyspnea and fatigue. Imaging revealed large thrombi in both atria, extending via PFO. Concurrent acute deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) were identified. Emergency cardiac surgery successfully removed the thrombi, emphasizing the diagnostic and management challenges associated with biatrial thrombus and PFO.

CONCLUSION

Point-of-care ultrasound (POCUS) plays a critical role in rapidly identifying TIT across a PFO. The time-sensitive and multidisciplinary medical management of TIT is crucial, requiring individualized strategies.

CLINICAL TRIAL NUMBER

Not applicable.

KEY CLINICAL MESSAGE

POCUS can be very helpful in providing a more appropriate image and more accurate diagnosis in patients with pulmonary embolism related to thrombus in transit (TIT) which is one of the most life-threatening medical conditions.

摘要

背景

移动性血栓(TIT)是一种罕见且危及生命的病症,存在肺栓塞和反常栓塞的风险,需要及时诊断。我们的病例报告强调了利用先进成像技术准确及时诊断TIT的重要性以及手术取栓术的潜在救命作用。本病例报告讨论了一例罕见的与静脉血栓栓塞(VTE)和卵圆孔未闭(PFO)相关的双房血栓病例。一名患有多种合并症的66岁女性出现呼吸困难和疲劳症状。影像学检查发现双房均有大血栓,经卵圆孔未闭延伸。同时还发现了急性下肢深静脉血栓形成(DVT)和肺血栓栓塞(PTE)。急诊心脏手术成功清除了血栓,凸显了与双房血栓和卵圆孔未闭相关的诊断和管理挑战。

结论

床旁超声(POCUS)在快速识别经卵圆孔未闭的TIT方面起着关键作用。TIT的时间敏感型多学科医疗管理至关重要,需要个体化策略。

临床试验编号

不适用。

关键临床信息

对于与移动性血栓(TIT)相关的肺栓塞患者,床旁超声(POCUS)有助于提供更合适的图像和更准确的诊断,而TIT是最危及生命的病症之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/066b3151a4e5/12872_2025_4798_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/2d8f4aa578b6/12872_2025_4798_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/8f0e3cd24727/12872_2025_4798_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/5d966251a9ee/12872_2025_4798_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/623127f6bbde/12872_2025_4798_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/066b3151a4e5/12872_2025_4798_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/2d8f4aa578b6/12872_2025_4798_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/8f0e3cd24727/12872_2025_4798_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/5d966251a9ee/12872_2025_4798_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/623127f6bbde/12872_2025_4798_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6fc/12103051/066b3151a4e5/12872_2025_4798_Fig5_HTML.jpg

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本文引用的文献

1
A Proposed Approach for the Management of Clot-in-Transit.一种针对血管内血栓的管理建议方法。
Cureus. 2022 Aug 27;14(8):e28481. doi: 10.7759/cureus.28481. eCollection 2022 Aug.
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Point of care ultrasound detection of thrombus straddling a patent foramen ovale in a patient with acute chest syndrome.床旁超声检测急性胸综合征患者卵圆孔未闭处的骑跨血栓。
Respir Med Case Rep. 2022 Aug 8;39:101724. doi: 10.1016/j.rmcr.2022.101724. eCollection 2022.
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Clot in Transit and Pulmonary Artery Percutaneous Mechanical Thrombectomy.行肺动脉经皮机械血栓切除术治疗移行性血栓
Kans J Med. 2021 Nov 5;14(3):287-289. doi: 10.17161/kjm.vol14.15601. eCollection 2021.
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Case report: Thrombus in transit-a cause of impending paradoxical embolism.病例报告:移行血栓——即将发生反常栓塞的一个原因。
Eur Heart J Case Rep. 2021 Feb 16;5(2):ytaa580. doi: 10.1093/ehjcr/ytaa580. eCollection 2021 Feb.
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Anticoagulation in chronic kidney disease: from guidelines to clinical practice.慢性肾脏病的抗凝治疗:从指南到临床实践。
Clin Cardiol. 2019 Aug;42(8):774-782. doi: 10.1002/clc.23196. Epub 2019 May 28.
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Large thrombus-in-transit within a patent foramen ovale in a patient with pulmonary embolism: a case report.一名肺栓塞患者卵圆孔未闭内存在大量移动性血栓:病例报告
J Int Med Res. 2018 Oct;46(10):4332-4337. doi: 10.1177/0300060518789820. Epub 2018 Aug 8.
7
Systematic Review of Treatment for Trapped Thrombus in Patent Foramen Ovale.卵圆孔未闭封堵术后封堵器内血栓形成治疗的系统评价
Korean Circ J. 2017 Sep;47(5):776-785. doi: 10.4070/kcj.2016.0295. Epub 2017 Sep 11.
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Right heart thrombus in transit: a series of two cases.移动性右心血栓:两例系列报道。
Crit Ultrasound J. 2017 Dec;9(1):14. doi: 10.1186/s13089-017-0069-9. Epub 2017 Jun 15.
9
Extensive biatrial thrombus straddling the patent foramen ovale and traversing into the left and right ventricle.广泛的双房血栓跨越卵圆孔未闭并延伸至左、右心室。
BMJ Case Rep. 2016 Nov 21;2016:bcr2016216761. doi: 10.1136/bcr-2016-216761.
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Successful lysis in massive pulmonary embolism with thrombus entrapped in PFO.卵圆孔未闭(PFO)合并血栓形成导致的大面积肺栓塞成功溶栓。
Am J Emerg Med. 2017 Jan;35(1):198.e3-198.e5. doi: 10.1016/j.ajem.2016.07.039. Epub 2016 Jul 25.