猫外分泌性胰腺肿瘤中淀粉样沉积物的特征分析。
Characterization of amyloid deposits in exocrine pancreatic tumors in cats.
作者信息
Sedghi Masoud Niki, Iwaide Susumu, Itoh Yoshiyuki, Hisada Miki, Harada Tomoyuki, Machida Noboru, Murakami Tomoaki
机构信息
Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Smart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, Tokyo, Japan.
出版信息
J Vet Diagn Invest. 2025 May 24:10406387251343842. doi: 10.1177/10406387251343842.
Some types of amyloidosis are observed as localized conditions associated with tumors, such as plasmacytoma and C-cell carcinoma. Although pancreatic endocrine tumors have been linked to amyloid deposition, the potential for amyloid formation in exocrine pancreatic tumors has remained unexplored in both animals and humans. We examined amyloid deposits in 24 feline cases of exocrine pancreatic tumors. Histologic analysis identified amyloid deposits in 8 cases, appearing as Congo red-positive amorphous material in the luminal corpora amylacea. Microdissection and mass spectrometry analysis of amyloid deposits from 5 cases identified lithostathine as the major component in 3 of the cases. Immunohistochemistry confirmed the presence of lithostathine in these deposits, identifying lithostathine-derived amyloid. Conversely, other cases had no consistent lithostathine positivity, indicating that multiple amyloidogenic proteins, not just lithostathine, may be involved in exocrine pancreatic tumor-associated amyloidosis.
某些类型的淀粉样变性被视为与肿瘤相关的局限性病症，如浆细胞瘤和C细胞癌。尽管胰腺内分泌肿瘤与淀粉样蛋白沉积有关，但外分泌性胰腺肿瘤中淀粉样蛋白形成的可能性在动物和人类中均未得到探索。我们检查了24例猫外分泌性胰腺肿瘤病例中的淀粉样蛋白沉积物。组织学分析在8例病例中发现了淀粉样蛋白沉积物，表现为管腔内淀粉样小体中刚果红阳性的无定形物质。对5例病例的淀粉样蛋白沉积物进行显微切割和质谱分析，在其中3例病例中确定石胆素为主要成分。免疫组织化学证实这些沉积物中存在石胆素，确定为石胆素衍生的淀粉样蛋白。相反，其他病例没有一致的石胆素阳性，这表明外分泌性胰腺肿瘤相关淀粉样变性可能涉及多种淀粉样蛋白生成蛋白，而不仅仅是石胆素。
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