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Individual Acute Exposures to Low Concentrations of Cadmium, Chromium, Lead, and Nickel Affect Oxidative Stress and Pathological Markers in Fruit Bats.

作者信息

Destro Ana Luiza Fonseca, Alves Thaís Silva, Dias Fernanda Ribeiro, Gonçalves Reggiani Vilela, de Oliveira Jerusa Maria, de Oliveira Leandro Licursi, Freitas Mariella Bontempo

机构信息

Department of Animal Biology, Federal University of Viçosa, Viçosa, MG 36570-900, Brazil.

Department of Structural Biology, Federal University of Triângulo Mineiro, Uberaba, MG 38025-350, Brazil.

出版信息

ACS Omega. 2025 May 8;10(19):19797-19807. doi: 10.1021/acsomega.5c00991. eCollection 2025 May 20.

DOI:10.1021/acsomega.5c00991
PMID:40415806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12096224/
Abstract

We investigated the effects of heavy metals on fruit-eating bats. Artibeus lituratus, a species that is not endangered, received a 1.5 mg/kg intraperitoneal (ipi) injection of cadmium (Cd), chromium (Cr), lead (Ld), or nickel (Ni). After 96 h, Ni-exposed bats showed oxidative stress in the liver and testes; the kidneys showed increased vascular congestion. Pb-exposed bats showed lower glutathione -transferase (GST) activity in all tested tissues and a decreased percentage of normal cells in the seminiferous tubules in the testes. Bats exposed to Cr showed lower GST activity in the kidneys and testes, higher leukocyte infiltrate in the liver, and higher vacuolization in the testes. Cd-exposed bats showed lower GST activity in all tissues, higher leucocyte infiltrate in the kidneys, and a lower percentage of normal cells in the testes. Necrotic and lipidic areas in the liver were observed in Pb-exposed and Ni-exposed bats. We propose the following toxicity order for fruit-eating bats: Ni > Pb > Cr = Cd.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e118/12096224/25c26ec0733d/ao5c00991_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e118/12096224/dd31d349ee3a/ao5c00991_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e118/12096224/2167dbb987d9/ao5c00991_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e118/12096224/25c26ec0733d/ao5c00991_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e118/12096224/dd31d349ee3a/ao5c00991_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e118/12096224/2167dbb987d9/ao5c00991_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e118/12096224/25c26ec0733d/ao5c00991_0003.jpg

相似文献

[1]
Individual Acute Exposures to Low Concentrations of Cadmium, Chromium, Lead, and Nickel Affect Oxidative Stress and Pathological Markers in Fruit Bats.

ACS Omega. 2025-5-8

[2]
Toxicology of arsenate, arsenite, cadmium, lead, chromium, and nickel in testes of adult Swiss mice after chronic exposure by intraperitoneal route.

J Trace Elem Med Biol. 2023-12

[3]
Tebuconazole-induced toxicity and the protective effect of Ficus carica extract in Neotropical fruit-eating bats.

Chemosphere. 2021-7

[4]
Exposure to the insecticide endosulfan induces liver morphology alterations and oxidative stress in fruit-eating bats (Artibeus lituratus).

Int J Exp Pathol. 2017-2

[5]
Exposure to deltamethrin induces oxidative stress and decreases of energy reserve in tissues of the Neotropical fruit-eating bat Artibeus lituratus.

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[6]
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Int J Exp Pathol. 2022-10

[7]
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[8]
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Environ Sci Pollut Res Int. 2021-4

[9]
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[10]
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Environ Toxicol. 2011-10-11

本文引用的文献

[1]
Trace metal accumulation with age in bats: a case study on Pipistrellus kuhlii lepidus from a relatively unpolluted area.

Environ Sci Pollut Res Int. 2024-12

[2]
A systematic review of trace elements in the tissues of bats (Chiroptera).

Environ Pollut. 2024-9-1

[3]
Iron and aluminum ore mining pollution induce oxidative and tissue damage on fruit-eating bats from the Atlantic Forest.

J Hazard Mater. 2024-3-5

[4]
Toxicology of arsenate, arsenite, cadmium, lead, chromium, and nickel in testes of adult Swiss mice after chronic exposure by intraperitoneal route.

J Trace Elem Med Biol. 2023-12

[5]
Intracellular GSH/GST antioxidants system change as an earlier biomarker for toxicity evaluation of iron oxide nanoparticles.

NanoImpact. 2021-7

[6]
Large-scale genome sampling reveals unique immunity and metabolic adaptations in bats.

Mol Ecol. 2021-12

[7]
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic.

Front Pharmacol. 2021-4-13

[8]
Short-term intake of deltamethrin-contaminated fruit, even at low concentrations, induces testicular damage in fruit-eating bats (Artibeus lituratus).

Chemosphere. 2021-9

[9]
Characterization of glutathione S-transferase enzyme from brown meagre (Sciaena umbra) and inhibitory effects of heavy metals.

Biotechnol Appl Biochem. 2022-2

[10]
Cadmium Exposure and Testis Susceptibility: a Systematic Review in Murine Models.

Biol Trace Elem Res. 2021-7

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