Rui Yang, Xin Tianyuan, Chen Yu, Xiang Beiyi, Chen Changwen, Dong Rong, Chen Zhe
Laboratory of Cough, Kunshan Key Laboratory of Chronic Cough, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, China.
Department of Physiology and Pharmacology, Southeast University, Nanjing, China.
Front Neurosci. 2025 May 9;19:1598027. doi: 10.3389/fnins.2025.1598027. eCollection 2025.
The sneeze reflex serves as a protective response of the human body to environmental stimuli, with its regulatory mechanism largely depending on a complex nervous system. Current research indicates that the sneeze reflex can be triggered by both internal and external stimuli, including light and temperature. The composition of its reflex arc involves the coordinated action of multiple neural structures. Recent in-depth studies on the mechanism of the sneeze reflex have revealed a growing association between this reflex and various diseases, such as allergic rhinitis and infectious diseases. However, existing research primarily focuses on elucidating the neurophysiological basis of the sneeze reflex and its related neural pathways. The manifestations and mechanisms of the sneeze reflex under different pathological states remain underexplored, thereby limiting the potential application of the sneeze reflex in clinical diagnosis and treatment. This review aims to discuss the physiological mechanisms and pathological manifestations associated with the sneeze reflex.
喷嚏反射是人体对环境刺激的一种保护性反应，其调节机制很大程度上依赖于复杂的神经系统。目前的研究表明，喷嚏反射可由内部和外部刺激触发，包括光线和温度。其反射弧的组成涉及多个神经结构的协同作用。最近对喷嚏反射机制的深入研究揭示了这种反射与多种疾病之间越来越多的关联，如过敏性鼻炎和传染病。然而，现有研究主要集中在阐明喷嚏反射的神经生理基础及其相关神经通路。不同病理状态下喷嚏反射的表现和机制仍未得到充分探索，从而限制了喷嚏反射在临床诊断和治疗中的潜在应用。本综述旨在探讨与喷嚏反射相关的生理机制和病理表现。
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