Galassi Taynah, Pacheco-Barrios Kevin, Gianlorenco Anna C, Fregni Felipe
Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02138, USA.
Postgraduate Program in Health Sciences, Experimental Neuroscience Laboratory, University of Southern Santa Catarina, Palhoça 88137-272, Brazil.
Biomedicines. 2025 May 2;13(5):1111. doi: 10.3390/biomedicines13051111.
This study examines the influence of body mass index (BMI) and systemic inflammation on the relationship between physical activity and chronic pain conditions. We used data from the National Health and Nutrition Examination Surveys (NHANES, 2003-2004 and 2009-2010 waves), a population-based representative sample of the US population. Chronic pain conditions (neck, low back, hip, joint pain, and migraine) were defined as persistent pain for more than three months using self-reported questionnaires. Vigorous and moderate physical activity and sedentary time were collected using validated instruments. Weighted logistic regression models were used to test the adjusted associations and effect modifications. We included 9809 individuals (mean age of 46.58 and 51% women). We found a protective adjusted association between vigorous physical activity and chronic neck, low back, and hip pain (2003-2004: OR = 0.798, 95% CI, 0.647-0.984; 2009-2010: OR = 0.629, 95% CI, 0.474-0.833). Consistently, higher sedentary time was associated with higher chronic pain prevalence. Likewise, vigorous physical activity was protective for chronic migraine pain (2003-2004: OR = 0.697, 95% CI, 0.517-0.939). However, it was not for chronic joint pain. Moderate physical activity does not have a protective association in our sample. Furthermore, this protective association was attenuated by high BMI levels ( = 0.011) and high CRP ( = 0.006). Vigorous physical activity has a protective association with chronic pain. People with obesity and high systemic inflammation presented an attenuated beneficial association. Our results suggest that pain condition, body composition, and systemic inflammation should be considered for the personalization of community-based physical activity interventions to prevent chronic pain conditions.
本研究探讨体重指数（BMI）和全身炎症对身体活动与慢性疼痛状况之间关系的影响。我们使用了来自美国国家健康与营养检查调查（NHANES，2003 - 2004年和2009 - 2010年波次）的数据，这是一个基于人群的美国人口代表性样本。慢性疼痛状况（颈部、下背部、臀部、关节疼痛和偏头痛）通过自我报告问卷定义为持续疼痛超过三个月。使用经过验证的工具收集剧烈和适度身体活动以及久坐时间。加权逻辑回归模型用于检验调整后的关联和效应修正。我们纳入了9809名个体（平均年龄46.58岁，51%为女性）。我们发现剧烈身体活动与慢性颈部、下背部和臀部疼痛之间存在保护性调整关联（2003 - 2004年：OR = 0.798，95%CI，0.647 - 0.984；2009 - 2010年：OR = 0.629，95%CI，0.474 - 0.833）。同样，久坐时间越长，慢性疼痛患病率越高。同样，剧烈身体活动对慢性偏头痛疼痛有保护作用（2003 - 2004年：OR = 0.697，95%CI，0.517 - 0.939）。然而，对慢性关节疼痛没有保护作用。在我们的样本中，适度身体活动没有保护关联。此外，这种保护关联因高BMI水平（P = 0.011）和高CRP（P = 0.006）而减弱。剧烈身体活动与慢性疼痛存在保护关联。肥胖和全身炎症高的人这种有益关联减弱。我们的结果表明，在基于社区的身体活动干预个性化以预防慢性疼痛状况时，应考虑疼痛状况、身体成分和全身炎症。
