Kaadan Amr, Salati Simona, Cadossi Ruggero, Aaron Roy
Department of Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Medical Division, Igea S.p.A., 41012 Carpi, Italy.
Bioengineering (Basel). 2025 Apr 30;12(5):474. doi: 10.3390/bioengineering12050474.
Pulsed Electromagnetic Field (PEMF) therapy has been shown to have substantial suppressive effects on inflammation and is a promising treatment for the modulation of inflammation. Several in vitro and in vivo studies have shown that PEMFs profoundly suppress inflammatory pathways, such as the NF-κB and MAPK signaling pathways, by lowering cytokine levels and improving extracellular matrix synthesis. This review describes studies, ranging from in vitro to clinical, that investigate the lesser-known roles of PEMF in the modulation of inflammation in soft tissue wound, cartilage, and joint healing, alongside angiogenesis. Mechanistically, PEMFs act via adenosine receptors, specifically A, which play a key role in inflammation modulation and tissue repair. In some clinical trials, PEMF has yielded short-term symptom relief and functional improvements in early-stage osteoarthritis patients, arthroscopy patients, and anterior cruciate ligament reconstruction patients.
脉冲电磁场（PEMF）疗法已被证明对炎症具有显著的抑制作用，是一种很有前景的炎症调节治疗方法。多项体外和体内研究表明，脉冲电磁场通过降低细胞因子水平和改善细胞外基质合成，深刻抑制炎症途径，如NF-κB和MAPK信号通路。本综述描述了从体外到临床的研究，这些研究探讨了脉冲电磁场在软组织伤口、软骨和关节愈合以及血管生成中的炎症调节中鲜为人知的作用。从机制上讲，脉冲电磁场通过腺苷受体，特别是A受体起作用，这些受体在炎症调节和组织修复中起关键作用。在一些临床试验中，脉冲电磁场已使早期骨关节炎患者、关节镜检查患者和前交叉韧带重建患者获得短期症状缓解和功能改善。
