Boyd A E, Sanchez-Franco F
J Clin Endocrinol Metab. 1977 May;44(5):985-9. doi: 10.1210/jcem-44-5-985.
Serum prolactin (PRL) and thyrotropin (TSH) levels were measured after iv administration of 200 microng of synthetic thyrotropin-releasing hormone (TRH) in 20 normal women ages 18 to 34. Ten women received TRH on days 7 to 8 of the menstrual cycle and 10 women received TRH on days 21-22. Although there was no difference in the dose of TRH relative to body weight in the two groups of women, the peak PRL level after TRH stimulation was greater in the women studied on day 21-22 (48.5+/-5.7 ng/ml, mean+/-SE) than on day 7-8 (35.2+/-4.2 ng/ml) of the cycle (P less than 0.05). In contrast, TSH rose to a greater degree in the preovulatory phase (13.8+/-1.8 micronU/ml) than the luteal phase (7.7+/-0.7 micronU/ml of the cycle (P less than .01). Studies of the PRL and TSH response after TRH administration should take the phase of the menstrual cycle into account.
在20名年龄在18至34岁的正常女性中，静脉注射200微克合成促甲状腺激素释放激素（TRH）后，测定血清催乳素（PRL）和促甲状腺激素（TSH）水平。10名女性在月经周期的第7至8天接受TRH，10名女性在第21 - 22天接受TRH。尽管两组女性中TRH相对于体重的剂量没有差异，但在月经周期第21 - 22天接受研究的女性中，TRH刺激后的PRL峰值水平（48.5±5.7纳克/毫升，均值±标准误）高于第7 - 8天（35.2±4.2纳克/毫升）（P<0.05）。相反，促排卵前期TSH升高程度（13.8±1.8微单位/毫升）大于黄体期（7.7±0.7微单位/毫升）（P<0.01）。TRH给药后PRL和TSH反应的研究应考虑月经周期阶段。
