Iglesias-Varea Javier, Fernández-Ruiz Mario, Domínguez Laura, Boán Jorge, Aparicio-Minguijón Eduardo, Terrón Antonio, Asín María Asunción Pérez-Jacoiste, Aguado José María, López-Medrano Francisco
Facultad de Medicina, Universidad Complutense, Madrid, España.
Unidad de Enfermedades Infecciosas, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, España.
Rev Esp Quimioter. 2025 May 27;38(4):294-304. doi: 10.37201/req/020.2025.
Infective endocarditis (IE) is a complex condition associated with high morbidity and mortality. The creation of multidisciplinary teams (endocarditis team) has been shown to improve its management and prognosis. We analysed the impact of the formal implementation of a multidisciplinary IE committee (coIE) in a tertiary care hospital.
Single-centre quasi-experimental study comparing two periods: before (2010-2015) and after (2017-2021) the implementation of the coIE. The coIE met weekly (and on demand when necessary) to make decisions regarding medical and surgical management in patients with definite or possible IE, following a protocol based on international guidelines.
We included 92 and 97 patients in the pre- and post-intervention periods, respectively. Demographic characteristics, predisposing factors, and types of IE were similar. No significant differences were observed in the proportion of patients with surgical indication who underwent surgery (30.2 % vs 39.1 %, respectively; p = 0.317), in-hospital mortality (27.2 % vs 34.0 %; p = 0.308), or one-year mortality (32.6 % vs 45.4 %; p = 0.073). The median (interquartile range) time from diagnosis to surgery decreased in the post-intervention period (11.5 [6.3-25.3] vs 7 [3-10] days; p = 0.026). The diagnosis of embolic events was more frequent in this period (46.7 % vs 58.8 %; p = 0.098).
Although we did not observe a significant impact on mortality among patients with definite IE after the implementation of an endocarditis team, we noted a favourable trend in intermediate indicators of healthcare quality.
感染性心内膜炎(IE)是一种复杂疾病,与高发病率和高死亡率相关。多学科团队(心内膜炎团队)的组建已被证明可改善其管理和预后。我们分析了在一家三级护理医院正式设立多学科IE委员会(coIE)的影响。
单中心准实验研究,比较两个时期:coIE实施前(2010 - 2015年)和实施后(2017 - 2021年)。coIE每周开会(必要时按需开会),根据基于国际指南的方案,就确诊或可能患有IE的患者的医疗和手术管理做出决策。
干预前和干预后时期分别纳入92例和97例患者。人口统计学特征、易感因素和IE类型相似。接受手术的有手术指征患者比例(分别为30.2%和39.1%;p = 0.317)、住院死亡率(27.2%和34.0%;p = 0.308)或一年死亡率(32.6%和45.4%;p = 0.073)均未观察到显著差异。干预后时期从诊断到手术的中位(四分位间距)时间缩短(11.5 [6.3 - 25.3]天对7 [3 - 10]天;p = 0.026)。这一时期栓塞事件的诊断更为频繁(46.7%对58.8%;p = 0.098)。
虽然在心内膜炎团队实施后,我们未观察到对确诊IE患者死亡率有显著影响,但我们注意到医疗质量的中间指标有良好趋势。