Neo Edmund J R, Lau Trier T N, Thein Khin Yamin, Tay San San
Department of Rehabilitation Medicine, Changi General Hospital, Singapore, Singapore.
Rehabilitation Medicine, SingHealth Residency, Singapore, Singapore.
Front Pain Res (Lausanne). 2025 May 13;6:1601708. doi: 10.3389/fpain.2025.1601708. eCollection 2025.
Knee osteoarthritis (OA) is a common joint disorder that causes significant pain and disability. It can affect individuals undergoing inpatient rehabilitation, interfering with their participation in therapy and clinical improvement. While there are various treatment options available for this condition, such as the intra-articular corticosteroid injection, not all patients are suitable and symptoms may persist despite multimodal analgesia. The ultrasound-guided genicular nerve block (US GNB) induces analgesia by targeting the genicular nerves around the knee, and has emerged as a safe and effective intervention option. This is the first effort to document its application in the inpatient rehabilitation setting.
This was a retrospective case series. We reviewed the medical records of inpatients undergoing rehabilitation who underwent the US GNB for disabling knee OA between July 1, 2022, and August 31, 2023. The primary outcome was improvement in rehabilitation participation based on physiotherapist notes in the week following the procedure. Secondary outcomes were pain by visual analogue scale (VAS), ambulation distance, and the Western Ontario and McMaster Universities Arthritis Index (WOMAC), at pre-discharge, 1-month, and 3-month follow-up timepoints. Safety and adverse events were also retrospectively reviewed.
Nine patients were consented for recruitment in our study. Eight of them showed improvement in pain and/or participation in therapy. There were significant improvements in VAS scores (median change -3) and improvements in ambulation distance (median increase 8 m) between pre-injection and pre-discharge phases. However, these did not persist at the longer follow-up visits. There were no serious adverse events although 3 patients had recurrent pain at later dates, and required further procedures or surgical referral.
The US GNB is safe to perform for inpatients undergoing rehabilitation who experience pain from knee OA. We found that in nearly all patients, there was clinical improvement in their pain and participation in therapy. It can be an effective alternative when other analgesia options are less desirable or available, and can help to keep patients progressing on the road to recovery.
膝骨关节炎(OA)是一种常见的关节疾病,会导致严重疼痛和功能障碍。它会影响接受住院康复治疗的患者,干扰他们参与治疗以及临床改善。虽然针对这种疾病有多种治疗选择,如关节内注射皮质类固醇,但并非所有患者都适用,而且尽管采用了多模式镇痛,症状仍可能持续。超声引导下膝神经阻滞(US GNB)通过靶向膝关节周围的膝神经来诱导镇痛,已成为一种安全有效的干预选择。这是首次记录其在住院康复环境中的应用。
这是一项回顾性病例系列研究。我们回顾了2022年7月1日至2023年8月31日期间因致残性膝骨关节炎接受US GNB治疗的住院康复患者的病历。主要结局是根据术后一周内物理治疗师的记录,康复参与度是否提高。次要结局包括出院前、1个月和3个月随访时间点的视觉模拟评分(VAS)疼痛评分、行走距离以及西安大略和麦克马斯特大学骨关节炎指数(WOMAC)。还对安全性和不良事件进行了回顾性分析。
9名患者同意参与我们的研究。其中8名患者的疼痛和/或治疗参与度有所改善。注射前和出院前阶段之间,VAS评分有显著改善(中位数变化 -3),行走距离也有所增加(中位数增加8米)。然而,在更长时间的随访中这些改善并未持续。尽管有3名患者在后期出现复发性疼痛,需要进一步治疗或转诊至外科,但没有严重不良事件发生。
对于因膝骨关节炎疼痛而接受康复治疗的住院患者,实施US GNB是安全的。我们发现几乎所有患者的疼痛和治疗参与度都有临床改善。当其他镇痛选择不太理想或无法获得时,它可以是一种有效的替代方法,并有助于患者在康复之路上不断进步。