[固定应激期间八月龄品系大鼠脑内核团中的儿茶酚胺]

[Catecholamines in nuclei of the brains of the August strain rat during immobilization stress].

作者信息

Ivanova T M, Kvetnanskiĭ R, Belova T I, Oprshalova Z, Dobrakovova M

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1985 Jul;71(7):823-8.

Abstract

Changes in epinephrine, norepinephrine and dopamine levels in different brain nuclei of the August rats were studied after 6.5-hr immobilization. The linkage between the BP dynamics under emotional stress and changes of catecholamines content was observed in epinephrinsynthetizing area A1, norepinephrinsynthetizing area A6 (locus Coeruleus) and dopaminsynthetizing area A9 (substantia nigra). Sharp increase of the BP in the August rats was related to obvious decrease of epinephrine content in A1, norepinephrine in locus coeruleus and dopamine in substantia nigra. The data obtained suggest that deficit of the catecholamines due to the metabolic changes during emotional stress may result in distutbances of the cardiovascular functions control in the August rats.

摘要

在对八月龄大鼠进行6.5小时固定后，研究了其不同脑核中肾上腺素、去甲肾上腺素和多巴胺水平的变化。在肾上腺素合成区域A1、去甲肾上腺素合成区域A6（蓝斑）和多巴胺合成区域A9（黑质）中，观察到了情绪应激下血压动态与儿茶酚胺含量变化之间的联系。八月龄大鼠血压的急剧升高与A1区域肾上腺素含量、蓝斑中去甲肾上腺素以及黑质中多巴胺的明显降低有关。所获得的数据表明，情绪应激期间代谢变化导致的儿茶酚胺缺乏可能会导致八月龄大鼠心血管功能控制紊乱。