Akyildiz Tezcan Ezgi, Tezcan Hüseyin
Department of Physical Medicine and Rehabilitation, Selcuk University Faculty of Medicine, Konya, Turkey.
Department of Cardiology, Selcuk University Faculty of Medicine, Konya, Turkey.
Medicine (Baltimore). 2025 May 30;104(22):e42694. doi: 10.1097/MD.0000000000042694.
Vitamin D deficiency is a global health issue, primarily recognized for its role in bone health and calcium absorption. Emerging research has expanded its significance to cardiovascular health. This study aimed to assess the influence of vitamin D deficiency on the frontal QRS-T (f[QRS-T]) angle on electrocardiograms, a potential marker of arrhythmic risk and cardiac mortality, to address a notable gap in the current understanding. In this prospective cross-sectional study, 357 individuals were assessed, with 75 excluded (60 for not meeting criteria, 10 declined, 5 other reasons). A total of 282 participants were grouped by vitamin D levels: vitamin D-deficient (<20 ng/mL, n = 185) and non-deficient (≥20 ng/mL, n = 97). After excluding 7 participants for incomplete tests, data from 275 (deficient: n = 180; non-deficient: n = 95) were analyzed. Electrocardiograms were evaluated by a blinded cardiologist, and data were analyzed with appropriate statistical methods. Our analysis revealed no significant differences in the demographic characteristics, laboratory findings, and f(QRS-T) angle between the groups with and without vitamin D deficiency. This study indicated that vitamin D deficiency does not significantly affect the f(QRS-T) angle in our sample, suggesting a limited role of vitamin D status in the risk of ventricular arrhythmias. These findings contribute to the discussion on the role of vitamin D in cardiovascular health and underscore the need for further studies to guide clinical decisions regarding vitamin D supplementation and cardiovascular risk management.
维生素D缺乏是一个全球性的健康问题，主要因其在骨骼健康和钙吸收中的作用而被人们所认识。新出现的研究已将其重要性扩展到心血管健康领域。本研究旨在评估维生素D缺乏对心电图额面QRS-T（f[QRS-T]）角的影响，f[QRS-T]角是心律失常风险和心脏死亡率的一个潜在标志物，以填补当前认识中的一个显著空白。在这项前瞻性横断面研究中，对357名个体进行了评估，其中75人被排除（60人不符合标准，10人拒绝，5人因其他原因）。根据维生素D水平将总共282名参与者分组：维生素D缺乏组（<20 ng/mL，n = 185）和非缺乏组（≥20 ng/mL，n = 97）。在排除7名测试不完整的参与者后，对275名（缺乏组：n = 180；非缺乏组：n = 95）的数据进行了分析。由一名不知情的心脏病专家对心电图进行评估，并使用适当的统计方法对数据进行分析。我们的分析显示，维生素D缺乏组和非缺乏组在人口统计学特征、实验室检查结果和f(QRS-T)角方面没有显著差异。本研究表明，在我们的样本中，维生素D缺乏并未显著影响f(QRS-T)角，这表明维生素D状态在室性心律失常风险中的作用有限。这些发现有助于关于维生素D在心血管健康中作用的讨论，并强调需要进一步研究以指导有关维生素D补充和心血管风险管理的临床决策。
