Sigg C, Hornstein O P
Hautarzt. 1985 Aug;36(8):441-8.
In order to find indications of underlying disorders, clinical, hormonal and spermatological examinations were conducted on 21 infertile male patients, who had shown increased exfoliation of immature germ cells in the ejaculate. However, no significant anamnestic, clinical or hormonal data were obtained. The differential spermiogram, on the other hand, revealed more or less uniform oligo-astheno-teratozoospermia, which was also characterized by frequent alteration of the middle and end pieces of the spermatozoa. In 11 of 21 patients, Ureaplasma urealyticum was demonstrated in the seminal plasma. Examination of the cellular fraction in the seminal fluid by impulse cytophotometry revealed a slight rise in the hyperhaploid peaks, a definite increase in the diploid peaks, and pronounced increase in the hypohaploid peaks. It remains debatable whether the hypohaploid peaks represent a karyolysis of exfoliated immature germ cells, an idiopathic decrease in the DNA content of sperm cells, an artificial fragmentation, or increased disintegration of spermatozoa. The frequency of seminal infections with U. urealyticum raises the question of whether or not the increased exfoliation of immature germ cells represents a specific alteration of the sperm cell precoursers.
为了寻找潜在疾病的迹象，对21名不育男性患者进行了临床、激素和精液学检查，这些患者的精液中未成熟生殖细胞的脱落有所增加。然而，未获得显著的既往史、临床或激素数据。另一方面，精子分类图显示或多或少均一的少弱畸精子症，其特征还在于精子中段和尾段频繁改变。21名患者中有11名在精浆中检测到解脲脲原体。通过脉冲细胞光度法对精液中的细胞成分进行检查，发现超单倍体峰略有升高，二倍体峰明显增加，亚单倍体峰显著增加。亚单倍体峰是否代表脱落的未成熟生殖细胞的核溶解、精子细胞DNA含量的特发性降低、人为碎片化或精子解体增加，仍存在争议。解脲脲原体精液感染的频率引发了一个问题，即未成熟生殖细胞脱落增加是否代表精子细胞前体的特异性改变。
