González Fernández J, Prieto-Torres L, Martínez-Domínguez S J, Barriendos Ambroj E, Ara Martín M
Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain; Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain.
Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain; Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain; Servicio de Digestivo, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; CIBERehd, Spain.
Actas Dermosifiliogr. 2025 Jul-Aug;116(7):T684-T691. doi: 10.1016/j.ad.2025.05.020. Epub 2025 May 28.
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of liver disease in our region, with a strong association with metabolic factors, such as obesity and diabetes. Recent studies reported that NAFLD was 1.5-3 times more common in psoriatic patients.
To calculate the diagnostic validity parameters of the triglyceride/glucose (TyG) index, and its combination with anthropometric parameters [body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHR)], as a non-invasive method for detecting NAFLD in patients with moderate-to-severe psoriasis.
We conducted a cross-sectional and single-center study with 149 patients with moderate-to-severe psoriasis. The ROC curves and the area under the curve (AUC) were calculated for the TyG index along with different anthropometric measures, using transient elastography as the reference test. The optimal cut-off point was calculated using Youden's index.
The prevalence of NAFLD was 64%. A total of 18% of these patients had significant liver fibrosis. The TyG index with anthropometric parameters showed a significant association with liver steatosis (P<.001). The TyG-BMI, TyG-WC, and TyG-WHR indices all showed an AUC>.83, while the TyG-BMI showed the highest AUC (0.852). Results were consistent in sex-based analyses.
The TyG index with anthropometric parameters-especially BMI-is an effective method for the initial screening of NAFLD in psoriatic patients.
非酒精性脂肪性肝病（NAFLD）是我们地区肝病最常见的病因之一，与肥胖和糖尿病等代谢因素密切相关。最近的研究报告称，NAFLD在银屑病患者中更为常见，是普通人群的1.5至3倍。
计算甘油三酯/葡萄糖（TyG）指数及其与人体测量参数[体重指数（BMI）、腰围（WC）和腰高比（WHR）]结合作为检测中重度银屑病患者NAFLD的非侵入性方法的诊断有效性参数。
我们对149例中重度银屑病患者进行了一项横断面单中心研究。以瞬时弹性成像为参考标准，计算TyG指数及不同人体测量指标的ROC曲线和曲线下面积（AUC）。使用约登指数计算最佳切点。
NAFLD患病率为64%。这些患者中共有18%患有显著肝纤维化。TyG指数与人体测量参数与肝脂肪变性显著相关（P<0.001）。TyG-BMI、TyG-WC和TyG-WHR指数的AUC均>0.83，而TyG-BMI的AUC最高（0.852）。基于性别的分析结果一致。
TyG指数与人体测量参数，尤其是BMI，是银屑病患者NAFLD初步筛查的有效方法。
