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急性心肌梗死后乳头肌破裂的经导管修复术

Transcatheter repair for papillary muscle rupture Post-AMI.

作者信息

Guo Fei, Zhu Guanghui, Yang Dongmei, Zhu Jing, Luo Jianfeng, Xu Jian

机构信息

Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.

Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

出版信息

BMC Cardiovasc Disord. 2025 May 30;25(1):418. doi: 10.1186/s12872-025-04877-4.

DOI:10.1186/s12872-025-04877-4
PMID:40448005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12124024/
Abstract

BACKGROUND

Rupture of the papillary muscle is a serious complication of acute myocardial infarction (AMI), usually leading to mitral valve dysfunction and severe regurgitation, which in turn causes acute heart failure, posing a significant threat to the patient's life.

CASE PRESENTATION

This case report aims to explore the feasibility and effectiveness of the DragonFly™ system in patients with papillary muscle rupture following AMI. We describe a 71-year-old male patient who was admitted due to chest tightness and chest pain, and upon examination, severe mitral regurgitation and papillary muscle rupture were found. Although the patient had missed the opportunity for emergency reperfusion, due to significant symptoms and heart failure, the cardiac team decided to perform a transcatheter edge-to-edge repair (TEER) of the mitral valve. During the procedure, guided by ultrasound and imaging, two valve clips were successfully implanted, significantly improving the mitral regurgitation. Postoperative assessment showed a reduction in regurgitation from 4 + to 1+, and the patient was discharged smoothly.

CONCLUSIONS

Patients with AMI accompanied by papillary muscle rupture have poor condition.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

乳头肌破裂是急性心肌梗死(AMI)的一种严重并发症,通常会导致二尖瓣功能障碍和严重反流,进而引起急性心力衰竭,对患者生命构成重大威胁。

病例报告

本病例报告旨在探讨DragonFly™系统在急性心肌梗死后乳头肌破裂患者中的可行性和有效性。我们描述了一名71岁男性患者,因胸闷和胸痛入院,检查发现严重二尖瓣反流和乳头肌破裂。尽管患者错过了紧急再灌注的机会,但由于症状严重且出现心力衰竭,心脏团队决定对二尖瓣进行经导管缘对缘修复(TEER)。手术过程中,在超声和成像引导下,成功植入了两个瓣膜夹,显著改善了二尖瓣反流。术后评估显示反流从4+降至1+,患者顺利出院。

结论

急性心肌梗死合并乳头肌破裂的患者病情较差。

临床试验编号

不适用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/12124024/6f880cea48bf/12872_2025_4877_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/12124024/3cc61a20337d/12872_2025_4877_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/12124024/6f880cea48bf/12872_2025_4877_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/12124024/3cc61a20337d/12872_2025_4877_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91ae/12124024/6f880cea48bf/12872_2025_4877_Fig2_HTML.jpg

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本文引用的文献

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Transcatheter edge-to-edge repair in severe mitral regurgitation following acute myocardial infarction - aetiology-based analysis.急性心肌梗死后严重二尖瓣反流的经导管缘对缘修复——基于病因的分析
Eur J Heart Fail. 2025 May;27(5):912-921. doi: 10.1002/ejhf.3582. Epub 2025 Jan 14.
2
The safety of transesophageal echocardiography to guide transcatheter tricuspid valve edge-to-edge repair.经食管超声心动图引导经导管三尖瓣瓣环成形术的安全性。
Echocardiography. 2024 Jun;41(6):e15861. doi: 10.1111/echo.15861.
3
Safety and efficacy of the DragonFly system for transcatheter valve repair of degenerative mitral regurgitation: one-year results of the DRAGONFLY-DMR trial.
用于退行性二尖瓣反流经导管瓣膜修复的DragonFly系统的安全性和有效性:DRAGONFLY-DMR试验的一年结果
EuroIntervention. 2024 Feb 19;20(4):e239-e249. doi: 10.4244/EIJ-D-23-00361.
4
Periprocedural Echocardiographic Guidance of Transcatheter Mitral Valve Edge-to-Edge Repair Using the MitraClip.经皮二尖瓣缘对缘修复术术中经食道超声心动图指导应用 MitraClip。
Interv Cardiol Clin. 2024 Jan;13(1):127-140. doi: 10.1016/j.iccl.2023.09.006.
5
Mitral valve transcatheter edge-to-edge repair.二尖瓣经导管缘对缘修复术。
EuroIntervention. 2023 Jan 23;18(12):957-976. doi: 10.4244/EIJ-D-22-00725.
6
Periprocedural Echocardiographic Guidance of Transcatheter Mitral Valve Edge-to-Edge Repair Using the MitraClip.经皮二尖瓣缘对缘修复术术中经食管超声心动图指导使用 MitraClip。
Cardiol Clin. 2021 May;39(2):267-280. doi: 10.1016/j.ccl.2021.01.009.
7
State of the Art: Transcatheter Edge-to-Edge Repair for Complex Mitral Regurgitation.技术现状:经导管缘对缘修复复杂二尖瓣反流
J Am Soc Echocardiogr. 2021 Oct;34(10):1025-1037. doi: 10.1016/j.echo.2021.03.240. Epub 2021 Apr 17.