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结合致病特征分析心脏手术患者术后肺炎的易感因素。

Combined pathogenic characteristics to analyze susceptibility factors of postoperative pneumonia in patients undergoing cardiac surgery.

作者信息

Li Jie, Wu Zhenhua, Xie Chang, Guo Zhigang

机构信息

Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300300, China.

出版信息

J Cardiothorac Surg. 2025 May 30;20(1):252. doi: 10.1186/s13019-025-03472-0.

Abstract

Postoperative infection prevention is crucial for cardiac surgery patients. This study enrolled 579 cardiac surgery patients from November 2021 to July 2022, reporting a 12.3% incidence of postoperative pneumonia. Blood sugar, Montreal Cognitive Assessment (MoCA) scores, respiratory failure, and complications were linked to respiratory infections. Significant differences in biomarkers, including creatine kinase, urine volume, alanine transaminase (ALT), hemoglobin, and PaO2/FiO2, were observed between pneumonia types. Bacterial pneumonia cases showed positive correlations between ALT, urine volume, and infection, while hemoglobin and PaO2/FiO2 correlated negatively. The most common pathogens were Klebsiella pneumoniae (20.3%), Acinetobacter baumannii (11.6%), and Pseudomonas aeruginosa (10.9%). Identifying susceptibility factors and pathogenic characteristics can guide effective prevention strategies. Monitoring and oxygen therapy remain essential for reducing postoperative pneumonia risk in cardiac surgery patients.

摘要

术后感染预防对于心脏手术患者至关重要。本研究纳入了2021年11月至2022年7月期间的579例心脏手术患者,报告术后肺炎发生率为12.3%。血糖、蒙特利尔认知评估(MoCA)评分、呼吸衰竭和并发症与呼吸道感染有关。在不同类型的肺炎之间,观察到生物标志物存在显著差异,包括肌酸激酶、尿量、丙氨酸转氨酶(ALT)、血红蛋白和PaO2/FiO2。细菌性肺炎病例中,ALT、尿量与感染呈正相关,而血红蛋白和PaO2/FiO2呈负相关。最常见的病原体是肺炎克雷伯菌(20.3%)、鲍曼不动杆菌(11.6%)和铜绿假单胞菌(10.9%)。识别易感因素和致病特征可指导有效的预防策略。监测和氧疗对于降低心脏手术患者术后肺炎风险仍然至关重要。

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