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常规退出式HIV筛查对急诊科运营指标的影响:务实随机HIV检测试验的结果

Effect of Routine Opt-Out HIV Screening on Emergency Department Operational Metrics: Results From the Pragmatic Randomized HIV TESTED Trial.

作者信息

Jones Austin T, Haukoos Jason, Hopkins Emily, Lyons Michael S, Rothman Richard E, White Douglas A E, Hsieh Yu-Hsiang, Joseph Kathleen M, Murray Evangelia, Rowan Sarah E

机构信息

Department of Emergency Medicine, Denver Health Medical Center, Denver, CO; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO.

Department of Emergency Medicine, Denver Health Medical Center, Denver, CO; Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO; Department of Epidemiology, Colorado School of Public Health, Aurora, CO; Colorado Social Emergency Medicine Collaborative, Denver, CO.

出版信息

Ann Emerg Med. 2025 Sep;86(3):240-251. doi: 10.1016/j.annemergmed.2025.04.011. Epub 2025 May 31.

Abstract

STUDY OBJECTIVE

To assess the effect of routine opt-out HIV screening on emergency department (ED) patient throughput.

METHODS

We performed a multicenter, prospective, pragmatic 3-arm, parallel-group, randomized clinical trial to evaluate the effectiveness of 3 triage-driven, opt-out HIV screening strategies-nontargeted, enhanced targeted, and traditional targeted screening-when fully integrated into usual ED practices. As the 3 screening approaches were performed concurrently, the trial was nested in an equivalent time samples quasi-experiment to allow for the evaluation of HIV screening on ED operational metrics. Hierarchical multivariable linear and log binomial regression were performed to estimate associations between opt-out HIV screening and patient wait time, length of stay, boarding time, door-to-door time, and left before treatment was complete.

RESULTS

From January 19, 2014, through July 7, 2016, a total of 377,392 patient visits were included, 125,743 (33.3%) of which were included from intervention periods. Among these visits, 65,093 (51.8%) were randomized into the HIV TESTED (HIV Testing Using Enhanced Screening Techniques in Emergency Departments) trial with 39,720 (61.0%) ultimately offered opt-out HIV testing. Of those offered HIV testing, 17,485 (44.0%) did not decline testing and 13,314 (33.5%) tests were completed. HIV screening was associated with an increase, on average, in wait time of 1.4 (95% confidence interval [CI] 0.3 to 2.6) minutes when adjusted for mode of arrival, acuity, overall crowding, time of day, and day of the week. HIV screening was negatively associated with length of stay for admitted patients (-18 [95% CI -30 to -4] minutes) and door-to-door time (-18 [95% CI -24 to -6] minutes), whereas HIV screening was not associated with length of stay for nonadmitted patients (-6 [95% CI -12 to 6] minutes) and boarding time (-6 [95% CI -42 to 24] minutes). Finally, HIV screening was associated with an increased prevalence of left before treatment was complete (prevalence ratio: 1.10, 95% CI 1.06 to 1.15) when adjusted for the same covariates.

CONCLUSIONS

When fully integrated into clinical ED care, routine opt-out HIV screening was associated with small but nonclinically meaningful increases in wait time and left before treatment was complete and no significant change in length of stay, boarding time, or door-to-door time.

摘要

研究目的

评估常规退出式HIV筛查对急诊科患者周转率的影响。

方法

我们进行了一项多中心、前瞻性、实用的三臂平行组随机临床试验,以评估三种由分诊驱动的退出式HIV筛查策略(非靶向、强化靶向和传统靶向筛查)在完全融入急诊科常规诊疗时的有效性。由于这三种筛查方法是同时进行的,该试验嵌套在一个等效时间样本准实验中,以评估HIV筛查对急诊科运营指标的影响。进行分层多变量线性回归和对数二项式回归,以估计退出式HIV筛查与患者等待时间、住院时间、待诊时间、从进院到出院时间以及治疗未完成前离开之间的关联。

结果

从2014年1月19日至2016年7月7日,共纳入377,392例患者就诊,其中125,743例(33.3%)来自干预期。在这些就诊患者中,65,093例(51.8%)被随机纳入“急诊科使用强化筛查技术进行HIV检测(HIV TESTED)”试验,最终39,720例(61.0%)接受了退出式HIV检测。在接受HIV检测的患者中,17,485例(44.0%)未拒绝检测,13,314例(33.5%)完成了检测。在对到达方式、病情严重程度、总体拥挤程度、一天中的时间和一周中的日期进行调整后,HIV筛查平均使等待时间增加了1.4分钟(95%置信区间[CI]为0.3至2.6)。HIV筛查与入院患者的住院时间(-18分钟[95%CI为-30至-4])和从进院到出院时间(-18分钟[95%CI为-24至-6])呈负相关,而HIV筛查与未入院患者的住院时间(-6分钟[95%CI为-12至6])和待诊时间(-6分钟[95%CI为-42至24])无关。最后,在对相同协变量进行调整后,HIV筛查与治疗未完成前离开的发生率增加相关(发生率比:1.10,95%CI为1.06至1.15)。

结论

当完全融入急诊科临床护理时,常规退出式HIV筛查与等待时间和治疗未完成前离开的小幅增加相关,但这些增加在临床上无意义,且住院时间、待诊时间或从进院到出院时间无显著变化。

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