基因补偿反应有助于疣螈肢体再生。

Genetic compensation response contributes to Pleurodeles waltl limb regeneration.

作者信息

Yin Binxu, Yu Changhao, Liu Yang, Cai Hao, Wu Wencheng, Ye Tingting, Wang Lei, Xiao Lujia, Zhu Yi, Guo Huaijuan, Zhang Kun, Wang Heng

机构信息

Central Laboratory and Orthopedic Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

College of Animal Science, Shandong Provincial Key Laboratory for Animal Germplasm Innovation & Utilization, Shandong Agricultural University, Taian, China.

出版信息

NPJ Regen Med. 2025 May 31;10(1):25. doi: 10.1038/s41536-025-00417-y.

DOI:10.1038/s41536-025-00417-y

PMID:40450023

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12126524/

Abstract

Hippo-Yap/Taz pathway is essential for tissue regeneration in multiple species. However, we found that in the highly regenerative salamanders, Yap knockout does not compromise the limb regeneration due to genetic compensation response (GCR). Specifically, the mutated Yap locus derived non-sense mRNA, which was recognized by UPF3A to instruct compensatory Taz induction. Blocking Yap mRNA or protein indeed inhibits regeneration. GCR could be utilized to maintain the robustness of limb regeneration.

摘要

河马-Yap/Taz信号通路对多种物种的组织再生至关重要。然而，我们发现，在具有高度再生能力的蝾螈中，由于基因补偿反应（GCR），Yap基因敲除并不影响肢体再生。具体而言，突变的Yap基因座产生无义mRNA，其被UPF3A识别以指导代偿性Taz诱导。阻断Yap mRNA或蛋白质确实会抑制再生。基因补偿反应可用于维持肢体再生的稳健性。