口服皮质类固醇剂量对CT增强多发性硬化斑块的影响。

The effect of oral corticosteroid dosage on CT enhancing multiple sclerosis plaques.

作者信息

Troiano R A, Hafstein M P, Zito G, Ruderman M I, Dowling P C, Cook S D

出版信息

J Neurol Sci. 1985 Aug;70(1):67-72. doi: 10.1016/0022-510x(85)90188-1.

Abstract

Fifty high-dose delayed CT scans were performed on 36 patients with definite MS within 4 months of a clinical relapse. The number of enhancing lesions visualized was compared in patients being treated with high- or low-dose oral corticosteroids and untreated controls. High-dose oral corticosteroid treatment significantly but incompletely reduced enhancement of MS plaques. Lower doses were less effective, especially when the latter were given on alternate days.

摘要

对36例临床复发后4个月内确诊为多发性硬化症（MS）的患者进行了50次大剂量延迟CT扫描。比较了接受高剂量或低剂量口服皮质类固醇治疗的患者及未治疗的对照组中可见强化病灶的数量。高剂量口服皮质类固醇治疗显著但未完全降低MS斑块的强化程度。较低剂量效果较差，尤其是隔日给药时。