Pund Ram, Vishwas Gopal, Madhukar Major, Pandey Krishna, Dhingra Sameer
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER) Hajipur, Export Promotions Industrial Park (EPIP), Industrial Area, Hajipur, Dist., Vaishali, Bihar, 844102, India.
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, Bihar, India.
J Health Popul Nutr. 2025 Jun 3;44(1):183. doi: 10.1186/s41043-025-00821-6.
This study was aimed to evaluates the quality of life using WHOQOL-BREF in VL patients co-infected with HIV in Bihar, India.
This cross-sectional study enrolled 240 participants: 60 HIV-VL co-infected, 60 HIV, 60 VL and 60 healthy individuals. Socio-demographic data and QOL assessments used the Hindi WHOQOL-BREF questionnaire. The data were compared using the chi-square test, One-Way ANOVA followed by Tukey's post-hoc Test. Generalised linear regression was performed for analyses of predictors of QOL, as well as the socio-economic status was determined by using the Modified Kuppuswamy socio-economic Scale 2022.
HIV-VL co-infected patients reported significantly lower QOL scores across all domains (physical, psychological, social relationships, and environmental) compared to healthy individuals (p < 0.05). Notably, psychological (12.17 ± 1.17), social relationship (5.90 ± 1.16), and environmental (14.10 ± 1.68) domains were severely impacted in HIV-VL coinfection in contrast to HIV (p < 0.05) and VL (p < 0.05).
HIV-VL co-infection profoundly affects quality of life, emphasizing the need for targeted interventions addressing psychological, social and environmental well-being. Future research should prioritize strategies improving QOL and assessing long-term treatment effects in HIV-VL co-infection.
本研究旨在使用世界卫生组织生活质量简表（WHOQOL - BREF）评估印度比哈尔邦同时感染艾滋病毒和内脏利什曼病（VL）患者的生活质量。
这项横断面研究招募了240名参与者：60名艾滋病毒 - VL合并感染者、60名艾滋病毒感染者、60名利什曼病患者和60名健康个体。社会人口统计学数据和生活质量评估使用印地语版的WHOQOL - BREF问卷。数据采用卡方检验、单因素方差分析及随后的Tukey事后检验进行比较。进行广义线性回归分析生活质量的预测因素，并使用2022年改良库普苏瓦米社会经济量表确定社会经济地位。
与健康个体相比，艾滋病毒 - VL合并感染患者在所有领域（身体、心理、社会关系和环境）的生活质量得分均显著较低（p < 0.05）。值得注意的是，与艾滋病毒感染（p < 0.05）和利什曼病感染（p < 0.05）相比，艾滋病毒 - VL合并感染对心理（12.17 ± 1.17）、社会关系（5.90 ± 1.16）和环境（14.10 ± 1.68）领域的影响更为严重。
艾滋病毒 - VL合并感染对生活质量有深远影响，强调需要针对心理、社会和环境福祉进行有针对性的干预。未来的研究应优先考虑改善生活质量的策略，并评估艾滋病毒 - VL合并感染的长期治疗效果。
