Jagdale Saili, Samanta Rajkumar, Narwade Mahavir, Haldar Niladri, Jadon Rajesh, Gajbhiye Virendra, Gajbhiye Kavita R
Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth, Pune, India.
Nanobioscience Group, Agharkar Research Institute, Pune, India.
Expert Rev Anticancer Ther. 2025 Aug;25(8):865-882. doi: 10.1080/14737140.2025.2515977. Epub 2025 Jun 11.
Breast cancer is one of the most common cancers in women and has a high mortality rate. Current treatment methods, including radiation, chemotherapy, and surgery, have limitations such as surrounding tissue damage and nonspecific toxicity, reducing their effectiveness. As a result, new therapeutic platforms are needed to enhance breast cancer treatment.
Nanoparticles, particularly metallic nanoparticles, have shown significant potential in overcoming the limitations of conventional treatments. These nanoparticles offer advantages such as high loading capacity, biocompatibility, adjustable size, and surface modification flexibility, making them ideal for drug delivery. This review focuses on the synthesis of metallic nanoparticles, emphasizing chemical and green synthesis methods. The green synthesis method has gained attention due to its eco-friendliness, biological safety, and cost-effectiveness. Research advancements in biosynthesized metallic nanoparticles for breast cancer therapy are discussed.
The use of bio-synthesized magnetic nanoparticles in the treatment of breast cancer shows promise for both cytotoxicity and targeted medication delivery. By increasing anti-tumor immune responses, their optical and magnetic qualities improve immunotherapy's efficacy. Furthermore, It have the potential to provide potent anticancer treatments and stimulate multidisciplinary research to address current obstacles in the treatment of breast cancer, opening up new therapeutic development pathways.