[Characteristics of early disorders of fatty-acid composition of kidney lipids in spontaneous (hereditary) arterial hypertension].

Fatty acid composition of kidney lipids from spontaneously hypertensive Okamoto-Aoki rats (SHR) and normotensive Wistar rats (NR) was investigated two days after birth by gas-liquid chromatography. In SHR kidney phospholipids, as compared to the respective NR values, the content of arachidonic acid (20:4n6) was decreased and the levels of oleic (18:1n9) and docosahexaenoic (22:6n3) acids were increased; in kidney triglycerides, the content of eicosatrionoic acid (20:3n9) and all fatty acids of the linoleic acid series was decreased, except the content of a polyunsaturated long-chain product of linoleic acid metabolism, docosapentaenoic acid (22:5n6) that was increased. These changes may have developed prenatally as a result of genetic peculiarities of SHR.