Cao Li-Ya, Zhao Yue, Chen Yang, Ma Pan, Xie Jiang-Chuan, Pan Xin-Mei, Zhang Xin, Chen Yong-Chuan, Wang Qian, Xie Lin-Li
Department of Pharmacy, the First Affiliated Hospital of Army Medical University (Third Military Medical University), Chongqing, China.
Pharmacy Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.
Front Immunol. 2025 May 20;16:1583116. doi: 10.3389/fimmu.2025.1583116. eCollection 2025.
Chimeric antigen receptor T (CAR-T) cell therapy has undergone vigorous development in recent years, yet it still faces significant challenges and difficulties in its clinical application and further development. A systematic synthesis of global trends in CAR-T clinical trials is essential to identify knowledge gaps, optimize treatment strategies, and guide future research directions. This review analyzed 1,580 CAR-T clinical trials registered at ClinicalTrials.gov as of April 2024, and extracted characteristic data in multiple dimensions, including target specificity, treatment indication, and development stage etc. The transparency of trial outcomes was assessed by validation with articles published in PubMed/Google Scholar. Additionally, it is complemented by investigator surveys assessing to barriers to CAR-T development, prospects, and recommendations.
嵌合抗原受体T（CAR-T）细胞疗法近年来得到了蓬勃发展，但其在临床应用和进一步发展中仍面临重大挑战和困难。系统综合CAR-T临床试验的全球趋势对于识别知识空白、优化治疗策略以及指导未来研究方向至关重要。本综述分析了截至2024年4月在ClinicalTrials.gov上注册的1580项CAR-T临床试验，并从多个维度提取了特征数据，包括靶点特异性、治疗适应症和研发阶段等。通过与PubMed/谷歌学术上发表的文章进行验证来评估试验结果的透明度。此外，还通过研究者调查对CAR-T发展的障碍、前景和建议进行了补充。
