Low back pain is the most common musculoskeletal condition in the adult population and still represents a global health problem. The initial and the most common treatment in 80% of all patients includes conservative management with pharmacotherapy for pain relief. If the symptoms persist or if there is minimal functional improvement after conservative treatment, minimally invasive interventions such as epidural steroid injections or percutaneous epidural adhesiolysis can be applied, or, in the worst cases, the patient should be considered for an open surgery procedure. Failed back surgery syndrome is a condition with a complex etiology, and many factors that predispose patients towards chronic pain. Epidural lysis of adhesions (LOA) represents an important element of the interventions for the treatment of low back pain that is refractory to more conventional methods.