Javeed Ghani Madiha, Van Eeckhoven Jens, Conradt Barbara
Cell and Developmental Biology, University College London, London, England, United Kingdom.
MicroPubl Biol. 2025 May 19;2025. doi: 10.17912/micropub.biology.001608. eCollection 2025.
During development 131 somatic cells reproducibly undergo programmed cell death. Many of these 131 cells 'programmed to die' are the smaller daughter of a neuroblast that divides asymmetrically and die through apoptosis. To determine whether cell size impacts the ability of cells programmed to die to undergo apoptosis, we increased or decreased embryo size by RNA interference-mediated knock-down of the genes or , respectively. We found that in apoptosis-compromised genetic backgrounds, ( ) enhances and ( ) partially suppresses inappropriate survival of cells programmed to die. This supports the notion that in embryos, an increase in cell size compromises and a decrease in cell size promotes the ability of cells programmed to die to undergo apoptosis.
在发育过程中，131个体细胞可重复地经历程序性细胞死亡。这131个“注定死亡”的细胞中，许多是神经母细胞不对称分裂产生的较小子代细胞，并通过凋亡死亡。为了确定细胞大小是否影响“注定死亡”细胞进行凋亡的能力，我们分别通过RNA干扰介导的基因或敲低来增加或减小胚胎大小。我们发现，在凋亡受损的遗传背景下，（）增强而（）部分抑制“注定死亡”细胞的不适当存活。这支持了这样一种观点，即在胚胎中，细胞大小的增加会损害而细胞大小的减小会促进“注定死亡”细胞进行凋亡的能力。
