Boyle Rory, Dehghani Nadia, Emrani Sheina, Wadhwani Anil R, Matyi Melanie, Cousins Katheryn A Q, Rhodes Emma, Nelson Brian, Stites Shana D, Xie Sharon X, Dratch Laynie, Van Deerlin Vivianna M, Snyder Allison, Irwin David, McMillan Corey T, Massimo Lauren
Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA.
medRxiv. 2025 May 13:2025.05.12.25327099. doi: 10.1101/2025.05.12.25327099.
Neighborhood deprivation has been associated with shorter survival, cognitive impairment and neurodegeneration in aging and Alzheimer's disease. However, the association of neighborhood deprivation with disease progression in behavioral-variant frontotemporal degeneration (bvFTD) is unknown.
We examined associations between tertiles of neighborhood deprivation, using the Area Deprivation Index (ADI), and survival in 311 individuals clinically diagnosed with bvFTD from the Penn Frontotemporal Degeneration (FTD) Center. In a subset of participants with complete baseline data across measures of global cognition, executive function, and language (n=163), we examined the association of ADI with longitudinal change.
Higher neighborhood deprivation was associated with shorter survival after symptom onset and faster decline in global cognition, executive and language functions, independent of genetic risk.
Living in more deprived neighborhoods (i.e. above the 50 percentile nationally) was associated with an accelerated disease course in bvFTD, highlighting an important socioeconomic disparity in disease prognosis.
邻里贫困与老年人及阿尔茨海默病患者的生存期缩短、认知障碍和神经退行性变有关。然而，邻里贫困与行为变异型额颞叶痴呆（bvFTD）疾病进展之间的关联尚不清楚。
我们使用区域剥夺指数（ADI）研究了邻里贫困三分位数与来自宾夕法尼亚额颞叶痴呆（FTD）中心的311例临床诊断为bvFTD的个体生存期之间的关联。在一组具有完整基线数据（涵盖整体认知、执行功能和语言测量）的参与者（n = 163）中，我们研究了ADI与纵向变化之间的关联。
邻里贫困程度较高与症状出现后的生存期较短以及整体认知、执行和语言功能的更快衰退相关，与遗传风险无关。
生活在贫困程度更高的社区（即全国贫困程度高于第50百分位数）与bvFTD疾病进程加速有关，突出了疾病预后方面重要的社会经济差异。
