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本文引用的文献

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The impact of adherence counseling incorporating a point of care urine tenofovir assay on virologic suppression among individuals failing tenofovir-lamivudine-dolutegravir: A pre-post intervention study.结合即时检验尿替诺福韦检测的依从性咨询对替诺福韦-拉米夫定-多替拉韦治疗失败个体病毒学抑制的影响：一项干预前后研究
Int J Infect Dis. 2025 Feb;151:107328. doi: 10.1016/j.ijid.2024.107328. Epub 2024 Dec 6.
2
The association between adherence to antiretroviral therapy and viral suppression under dolutegravir-based regimens: an observational cohort study from Uganda.基于多替拉韦方案的抗逆转录病毒治疗依从性与病毒抑制之间的关联：来自乌干达的一项观察性队列研究。
J Int AIDS Soc. 2024 Aug;27(8):e26350. doi: 10.1002/jia2.26350.
3
A point-of-care tenofovir urine test improves accuracy of self-reported preexposure prophylaxis adherence and increases condomless sex reporting among young women.即时检测尿液中的替诺福韦可提高自我报告的暴露前预防用药依从性的准确性，并增加年轻女性无保护性行为的报告。
AIDS. 2024 Nov 15;38(14):1965-1971. doi: 10.1097/QAD.0000000000003988. Epub 2024 Aug 7.
4
Impact of a point-of-care urine tenofovir assay on adherence to HIV pre-exposure prophylaxis among women in Kenya: a randomised pilot trial.肯尼亚基于即时检测点尿液替诺福韦检测的 HIV 暴露前预防用药依从性的影响：一项随机试点试验。
Lancet HIV. 2024 Aug;11(8):e522-e530. doi: 10.1016/S2352-3018(24)00125-5. Epub 2024 Jul 5.
5
Urine point-of-care tenofovir test demonstrates strong predictive clinical and research utility.即时检验尿中替诺福韦试验显示出强大的临床预测和研究效用。
AIDS. 2023 Dec 1;37(15):2381-2387. doi: 10.1097/QAD.0000000000003710. Epub 2023 Sep 5.
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Point-of-care urine tenofovir testing to predict HIV drug resistance among individuals with virologic failure.即时检测尿液中的替诺福韦以预测病毒学失败患者的 HIV 耐药性。
AIDS. 2023 Jun 1;37(7):1109-1113. doi: 10.1097/QAD.0000000000003520. Epub 2023 Feb 16.
7
Urine Tenofovir Levels Strongly Correlate With Virologic Suppression in Patients With Human Immunodeficiency Virus on Tenofovir Alafenamide-Based Antiretroviral Therapy.基于替诺福韦艾拉酚胺的抗逆转录病毒治疗的人类免疫缺陷病毒患者中，尿替诺福韦水平与病毒学抑制强烈相关。
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Point-of-Care Tenofovir Urine Testing for the Prediction of Treatment Failure and Drug Resistance During Initial Treatment for Human Immunodeficiency Virus Type 1 (HIV-1) Infection.即时检测 HIV-1 感染者治疗初期尿液替诺福韦预测治疗失败和耐药性
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Development and validation of the first point-of-care assay to objectively monitor adherence to HIV treatment and prevention in real-time in routine settings.开发并验证首个即时床旁检测方法，以在常规环境中实时、客观地监测艾滋病毒治疗和预防的依从性。
AIDS. 2020 Feb 1;34(2):255-260. doi: 10.1097/QAD.0000000000002395.
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Brief Report: Validation of a Urine Tenofovir Immunoassay for Adherence Monitoring to PrEP and ART and Establishing the Cutoff for a Point-of-Care Test.简报：用于监测 PrEP 和 ART 依从性的尿液替诺福韦免疫测定法的验证及建立即时检测的临界点。
J Acquir Immune Defic Syndr. 2019 May 1;81(1):72-77. doi: 10.1097/QAI.0000000000001971.

即时护理尿液自我检测用于测量替诺福韦依从性并预测病毒抑制的可行性。

Feasibility of Point-of-Care Urine Self-Testing to Measure Tenofovir Adherence and Predict Viral Suppression.

作者信息

Buccheri Renata, Spinelli Matthew A, Heise Megan J, Glidden David V, Sassaman Kevin, Martinson Tyler, Schmidt Hannah R, D'Angelo Alexa B, Duncan Dustin T, Horvath Keith J, Hirshfield Sabina, Williams Renessa S, Johnson Mallory O, Grov Christian, Carrico Adam, Gandhi Monica

机构信息

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.

Vitalant Research Institute, San Francisco, California, USA.

出版信息

Open Forum Infect Dis. 2025 May 17;12(6):ofaf300. doi: 10.1093/ofid/ofaf300. eCollection 2025 Jun.

DOI:10.1093/ofid/ofaf300
PMID:40463832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12131155/
Abstract

This study is the first to demonstrate the feasibility of at-home adherence monitoring using a point-of-care urine assay for tenofovir (TFV). Undetectable TFV is strongly associated with lower viral suppression (odds ratio, 0.19, 95% CI, 0.10-0.34; < .001), supporting a streamlined, effective approach for monitoring adherence between viral load assessments.

摘要

本研究首次证明了使用即时检验尿液分析法监测替诺福韦（TFV）居家依从性的可行性。未检测到TFV与较低的病毒抑制密切相关（比值比为0.19，95%置信区间为0.10 - 0.34；P <.001），这支持了一种在病毒载量评估之间监测依从性的简化有效方法。