即时护理尿液自我检测用于测量替诺福韦依从性并预测病毒抑制的可行性。

Feasibility of Point-of-Care Urine Self-Testing to Measure Tenofovir Adherence and Predict Viral Suppression.

作者信息

Buccheri Renata, Spinelli Matthew A, Heise Megan J, Glidden David V, Sassaman Kevin, Martinson Tyler, Schmidt Hannah R, D'Angelo Alexa B, Duncan Dustin T, Horvath Keith J, Hirshfield Sabina, Williams Renessa S, Johnson Mallory O, Grov Christian, Carrico Adam, Gandhi Monica

机构信息

Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.

Vitalant Research Institute, San Francisco, California, USA.

出版信息

Open Forum Infect Dis. 2025 May 17;12(6):ofaf300. doi: 10.1093/ofid/ofaf300. eCollection 2025 Jun.

DOI:10.1093/ofid/ofaf300

PMID:40463832

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12131155/

Abstract

This study is the first to demonstrate the feasibility of at-home adherence monitoring using a point-of-care urine assay for tenofovir (TFV). Undetectable TFV is strongly associated with lower viral suppression (odds ratio, 0.19, 95% CI, 0.10-0.34; < .001), supporting a streamlined, effective approach for monitoring adherence between viral load assessments.

摘要

本研究首次证明了使用即时检验尿液分析法监测替诺福韦（TFV）居家依从性的可行性。未检测到TFV与较低的病毒抑制密切相关（比值比为0.19，95%置信区间为0.10 - 0.34；P <.001），这支持了一种在病毒载量评估之间监测依从性的简化有效方法。