综述文章：脑转移瘤的立体定向放射外科治疗

Alalawi Reem Arif, Khriji Selma Alazhar, Ambusaidi Maram Abdullah, Al-Saadi Tariq

Royal college of Surgeons Ireland.

College of Medicine at Sultan Qaboos University.

Gulf J Oncolog. 2025 Jan;1(47):14-23.

BACKGROUND

Brain metastases pose a significant challenge in oncology, contributing to morbidity and mortality rates. These metastases originates from primary tumors in the breast, lung, and melanoma tumors and has promoted the exploration of several treatment modalities, including stereotactic radiosurgery (SRS). SRS is considered to be one of the most effective treatments for brain metastases due to its precision in delivering high doses of radiation with low damage to the surrounding tissues.

METHOD

A search of Scopus database was conducted using key terms like "stereotactic," "radiosurgery," "brain metastasis," and "SRS". Relevant articles were screened based on title, abstract, and full text. The top 100 articles, ranked by citation frequency, were included, and analysed for various details including title, first author, publication year, journal name, journal impact factor, country of first author, country of study, first author institution, corresponding author institution, study design, patient involvement, number of patients studied, primary aim, source of metastasis, and study conclusion.

RESULTS

The top 100 cited articles on SRS for brain metastases were identified, with an average citation of 149 citations per article. The study found that the USA, followed by Japan and Switzerland, produced the highest number of publications on stereotactic radiosurgery for brain metastasis. The University of Pittsburgh was the leading institution in the USA. The analysis showed an increasing trend in publications from 2007 to 2017, with a peak in 2010, followed by a decline, potentially influenced by the COVID-19 pandemic.

CONCLUSION

Stereotactic radiosurgery (SRS) is an effective treatment for brain metastases, delivering precise high-dose radiation with rapid dose fall-off. This study revealed that the USA, particularly the University of Pittsburgh, has produced the most publications on this topic. This information can help clinicians and researchers identify valuable articles and journals related to SRS.

背景

脑转移瘤是肿瘤学领域的一项重大挑战，会导致发病率和死亡率上升。这些转移瘤起源于乳腺、肺部和黑色素瘤的原发性肿瘤，并推动了包括立体定向放射外科手术（SRS）在内的多种治疗方式的探索。由于SRS能够精确地高剂量辐射且对周围组织损伤较小，因此被认为是治疗脑转移瘤最有效的方法之一。

方法

使用“立体定向”“放射外科手术”“脑转移瘤”和“SRS”等关键词在Scopus数据库中进行搜索。根据标题、摘要和全文筛选相关文章。纳入按引用频率排名的前100篇文章，并对标题、第一作者、出版年份、期刊名称、期刊影响因子、第一作者所在国家、研究所在国家、第一作者机构、通讯作者机构、研究设计、患者参与情况、研究患者数量、主要目的、转移来源和研究结论等各种细节进行分析。

结果

确定了关于SRS治疗脑转移瘤的被引用次数最多的前100篇文章，每篇文章平均被引用149次。研究发现，美国发表的关于脑转移瘤立体定向放射外科手术的文章数量最多，其次是日本和瑞士。匹兹堡大学是美国的领先机构。分析显示，2007年至2017年发表的文章呈上升趋势，2010年达到峰值，随后下降，这可能受到了新冠疫情的影响。