Zhi Hong, Xu Chengyi, Yan Hua, Liu Chengwei, Liu Li
Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, China.
Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Front Cardiovasc Med. 2025 May 21;12:1527887. doi: 10.3389/fcvm.2025.1527887. eCollection 2025.
Studies have shown that the occurrence and mortality of ischemic heart disease (IHD) in young women aged 35-54 years have increased despite improving trends globally among the general population. Common risk factors such as hypertension, hyperlipidemia, diabetes and smoking play an important role in the occurrence of IHD, but some rare causes that are easily misdiagnosed or undiagnosed should also be paid attention to. Here, we report the case of a young woman (33 years old) who suffered from recurrent acute myocardial infarction (AMI) and was ultimately diagnosed with Turner syndrome (TS) by karyotype testing. TS was identified as the cause of IHD in this patient. We then adjusted treatment strategy to include long-term estrogen-progestin therapy in addition to conventional treatment for IHD (e.g., anti-platelet, lipids-lowering). The patient has been followed up on an outpatient basis and is in good clinical condition. In this report, we highlighted the important of identifying rare causes when treating young women with IHD, and we also discussed the guideline management in such patients.
研究表明，尽管全球普通人群中缺血性心脏病（IHD）的发病趋势有所改善，但35 - 54岁年轻女性中IHD的发病率和死亡率仍有所上升。高血压、高脂血症、糖尿病和吸烟等常见危险因素在IHD的发生中起重要作用，但一些易被误诊或漏诊的罕见病因也应予以关注。在此，我们报告一例年轻女性（33岁）反复发生急性心肌梗死（AMI），最终经染色体核型检测确诊为特纳综合征（TS）的病例。TS被确定为该患者IHD的病因。然后，我们调整了治疗策略，除了IHD的常规治疗（如抗血小板、降脂）外，还包括长期雌激素 - 孕激素治疗。该患者一直在门诊随访，临床状况良好。在本报告中，我们强调了在治疗年轻IHD女性时识别罕见病因的重要性，并且我们还讨论了此类患者的指南管理。
