Xie Huiyi, Chen Yikai, Xu Shangcheng, Miao Nan, Zheng Wenwei, Jiang Chengji, Sun Tao
Center for Precision Medicine, School of Medicine, Huaqiao University, Xiamen, China.
Center for Reproductive Medicine, Quanzhou Women and Children's Hospital, Quanzhou, China.
Front Aging. 2025 May 21;6:1603916. doi: 10.3389/fragi.2025.1603916. eCollection 2025.
As the fertility risks for older males such as infertility and reduced success rates are on the rise, an increasing number of individuals are turning to Assisted Reproductive Technology (ART) to have offspring. However, the influence of paternal age on fertility and pregnancy outcomes in ART cycles remains ambiguous. Here, we analyzed the sperm quality of 6,805 samples and DNA fragmentation index (DFI) of 1,253 samples from Chinese males aged 20-63 years old. Our findings demonstrated that sperm volume, progressive motility, and total motility significantly decline, while sperm DFI increases as paternal age advances. Additionally, by studying 1,205 cases undergoing ART treatment, we discovered that male age and sperm quality do not exhibit a pronounced impact on ART outcomes. Our study has disclosed that sperm quality and DFI are inversely correlated with increasing male age. Our data further suggest that male ages do not significantly affect ART outcomes, which should offer instructive references for ART practice involving older males.
随着诸如不育和成功率降低等老年男性生育风险的增加，越来越多的人转向辅助生殖技术（ART）来生育后代。然而，父亲年龄对ART周期中生育能力和妊娠结局的影响仍不明确。在此，我们分析了6805份来自20至63岁中国男性样本的精子质量以及1253份样本的DNA碎片指数（DFI）。我们的研究结果表明，随着父亲年龄的增长，精液量、前向运动率和总运动率显著下降，而精子DFI增加。此外，通过研究1205例接受ART治疗的病例，我们发现男性年龄和精子质量对ART结局没有明显影响。我们的研究表明，精子质量和DFI与男性年龄增长呈负相关。我们的数据进一步表明，男性年龄对ART结局没有显著影响，这应为涉及老年男性的ART实践提供指导性参考。
