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核心技术专利：CN118964589B侵权必究
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通过HIF-1α/VEGF通路用于三阴性乳腺癌协同治疗和缓解疼痛的产氧仿生纳米草药系统

Oxygen-Generating Biomimetic Nano-Herb System for Synergistic Therapy & Pain Relief in Triple-Negative Breast Cancer via HIF-1α/VEGF Pathway.

作者信息

Cao Dian-Chao, Liang Yan, Guo Yang, Wu Dong-Yang, Wang Na-Na, Li Yan-Mei, Sun Hong-Fang, Wang Qin, Zhang Xia, Chi Yong-Liang, Sun Pei-Pei, Li You-Jie, Wang Ran-Ran, Wang Ping-Yu, Xie Shu-Yang, Xie Ning

机构信息

Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong, 264003, People's Republic of China.

Department of General Surgery, the second Medical College, Yantai Affiliated Hospital, Binzhou Medical University, Yantai, Shandong, 264003, People's Republic of China.

出版信息

Int J Nanomedicine. 2025 May 31;20:7113-7132. doi: 10.2147/IJN.S523754. eCollection 2025.

DOI:10.2147/IJN.S523754
PMID:40470112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12136069/
Abstract

PURPOSE: This study aims to develop an innovative delivery system, (Q+M/MnOx)@Clip, to enhance the bioavailability and therapeutic efficacy of quercetin both in tumor treatment and pain alleviation. METHODS: The (Q+M/MnOx)@Clip system was evaluated to enhance the release of quercetin, investigate its ability to target cancer cells, alleviate tumor hypoxia, and improve the efficacy of chemodynamic therapy (CDT). Tumor hypoxia markers and immune response activation were assessed, along with the impact on pain relief biomarkers. RESULTS: (Q+M/MnOx)@Clip successfully mitigated tumor hypoxia, facilitated controlled Q release, and enhanced CDT in vitro and in vivo. The system demonstrated a dual therapeutic effect: anti-tumor immunity and significant cancer pain relief by reducing HIF-1α and VEGF-A levels. CONCLUSION: The novel (Q+M/MnOx)@Clip system represents a promising advancement in nanomedicine, improving the bioavailability of quercetin and offering a more effective approach to cancer treatment by downregulation of HIF-1α and VEGF-A. This study demonstrates the potential for combining anti-tumor immunity with pain relief for triple-negative breast cancer therapy.

摘要

目的：本研究旨在开发一种创新的递送系统（Q+M/MnOx）@Clip，以提高槲皮素在肿瘤治疗和疼痛缓解方面的生物利用度和治疗效果。 方法：对（Q+M/MnOx）@Clip系统进行评估，以增强槲皮素的释放，研究其靶向癌细胞的能力、缓解肿瘤缺氧以及提高化学动力学疗法（CDT）疗效的能力。评估肿瘤缺氧标志物和免疫反应激活情况，以及对疼痛缓解生物标志物的影响。 结果：（Q+M/MnOx）@Clip成功减轻了肿瘤缺氧，促进了槲皮素的可控释放，并在体外和体内增强了CDT。该系统显示出双重治疗效果：通过降低HIF-1α和VEGF-A水平实现抗肿瘤免疫和显著缓解癌症疼痛。 结论：新型（Q+M/MnOx）@Clip系统代表了纳米医学领域一项有前景的进展，通过下调HIF-1α和VEGF-A提高了槲皮素的生物利用度，并为癌症治疗提供了一种更有效的方法。本研究证明了将抗肿瘤免疫与疼痛缓解相结合用于三阴性乳腺癌治疗的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/5b364372f36b/IJN-20-7113-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/3eaddb4e50fe/IJN-20-7113-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/3158b974b7a2/IJN-20-7113-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/f4f9533970cb/IJN-20-7113-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/af5473fc4e46/IJN-20-7113-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/38dfcfd19c10/IJN-20-7113-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/cb0fe7598bcf/IJN-20-7113-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/911cf7426754/IJN-20-7113-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/a199031a6b53/IJN-20-7113-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/5b364372f36b/IJN-20-7113-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/3eaddb4e50fe/IJN-20-7113-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/3158b974b7a2/IJN-20-7113-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/f4f9533970cb/IJN-20-7113-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/af5473fc4e46/IJN-20-7113-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/38dfcfd19c10/IJN-20-7113-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/cb0fe7598bcf/IJN-20-7113-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/911cf7426754/IJN-20-7113-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/a199031a6b53/IJN-20-7113-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fb/12136069/5b364372f36b/IJN-20-7113-g0009.jpg

相似文献

[1]
Oxygen-Generating Biomimetic Nano-Herb System for Synergistic Therapy & Pain Relief in Triple-Negative Breast Cancer via HIF-1α/VEGF Pathway.

Int J Nanomedicine. 2025-5-31

[2]
Ononin promotes radiosensitivity in lung cancer by inhibiting HIF-1α/VEGF pathway.

Phytomedicine. 2024-3

[3]
Hypoxia inducible factor-1α/vascular endothelial growth factor signaling activation correlates with response to radiotherapy and its inhibition reduces hypoxia-induced angiogenesis in lung cancer.

J Cell Biochem. 2018-6-15

[4]
HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs).

Breast Cancer Res. 2013

[5]
Inhibition of breast cancer proliferation and metastasis by strengthening host immunity with a prolonged oxygen-generating phototherapy hydrogel.

J Control Release. 2019-7-22

[6]
Potent inhibition of tumoral hypoxia-inducible factor 1alpha by albendazole.

BMC Cancer. 2010-4-15

[7]
Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) through inhibiting protein synthesis.

J Cell Biochem. 2008-10-1

[8]
HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model.

Int J Oncol. 2017-6-27

[9]
Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration.

PLoS One. 2009-10-29

[10]
Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells.

Biochem Pharmacol. 2013-2-14

本文引用的文献

[1]
A pH and glutathione-responsive carbon monoxide-driven nano-herb delivery system for enhanced immunotherapy in colorectal cancer.

J Control Release. 2024-12

[2]
Glucosylated Nanovaccines for Dendritic Cell-Targeted Antigen Delivery and Amplified Cancer Immunotherapy.

ACS Nano. 2024-9-17

[3]
Tumor microenvironment responsive nano-herb and CRISPR delivery system for synergistic chemotherapy and immunotherapy.

J Nanobiotechnology. 2024-6-19

[4]
Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody.

J Exp Clin Cancer Res. 2024-4-23

[5]
Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19.

J Nanobiotechnology. 2024-4-12

[6]
Dual targetable drug delivery system based on cell membrane camouflaged liposome for enhanced tumor targeting and improved anti-tumor efficiency.

Colloids Surf B Biointerfaces. 2024-6

[7]
In situ bio-mineralized Mn nanoadjuvant enhances anti-influenza immunity of recombinant virus-like particle vaccines.

J Control Release. 2024-4

[8]
Hybrid Ginseng-derived Extracellular Vesicles-Like Particles with Autologous Tumor Cell Membrane for Personalized Vaccination to Inhibit Tumor Recurrence and Metastasis.

Adv Sci (Weinh). 2024-5

[9]
A Single-Atom Manganese Nanozyme Mn-N/C Promotes Anti-Tumor Immune Response via Eliciting Type I Interferon Signaling.

Adv Sci (Weinh). 2024-4

[10]
Mno Nanoenzyme Armed CAR-NK Cells Enhance Solid Tumor Immunotherapy by Alleviating the Immunosuppressive Microenvironment.

Adv Healthc Mater. 2024-4

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