Vilà-Canet Gemma, Isart-Torruella Anna, Del Arco Alex, Manzano Demian, Rodriguez-Rubio David, Samper-Castellano Maria, Suárez-López Amaya, Lafuente Jesús
Hospital Del Mar, Barcelona, Spain.
Pompeu Fabra University, Barcelona, Spain.
Eur Spine J. 2025 Jun 5. doi: 10.1007/s00586-025-09006-5.
The objective of the study is to analyze the presence of Cutibacterium Acnes in the skin, subcutaneous tissue and deep tissue when performing primary lumbar spine surgery for degenerative pathology.
prospective study including consecutive patients, over 18 years of age, who underwent surgery for degenerative lumbar spine pathology through a posterior approach for the first time. 8 samples were obtained, 6 at the beginning of the intervention (2 skin, 2 subcutaneous, 2 deep tissue) and 2 at the end (1 deep tissue, 1 subcutaneous) for each patient following the Oxford protocol. Age, sex, and presence of previous facet/epidural infiltrations were recorded.
560 tissue samples were obtained from the 70 patients included. 52.8% were men, with an average of 56.2 years (SD 16.71). 57 samples were positive corresponding to 19 patients (27%). Men (p < 0.008) and patients under 50 years of age (p < 0.018) had more positive cultures. 71% of patients with positive deep tissue at the end of the intervention initially had positive samples in skin or subcutaneous tissue. According to the multivariate logistic regression analysis carried out adjusted for age and sex, having a positive skin and/or subcutaneous tissue sample obtained at the beginning of the intervention implies a 20 times greater risk of having a positive deep tissue culture at the end of the procedure (p 0,00).
The results of this study show a colonization rate of Cutibacterium Acnes of 27%,with a higher incidence found in young males.
本研究的目的是分析在对退行性病变进行初次腰椎手术时，皮肤、皮下组织和深部组织中痤疮丙酸杆菌的存在情况。
一项前瞻性研究，纳入连续的、年龄超过18岁、首次通过后路进行退行性腰椎病变手术的患者。按照牛津协议，为每位患者获取8个样本，干预开始时6个（2个皮肤样本、2个皮下组织样本、2个深部组织样本），结束时2个（1个深部组织样本、1个皮下组织样本）。记录年龄、性别以及既往小关节/硬膜外浸润情况。
从纳入的70例患者中获取了560个组织样本。52.8%为男性，平均年龄56.2岁（标准差16.71）。57个样本呈阳性，对应19例患者（27%）。男性（p＜0.008）和50岁以下患者（p＜0.018）的培养阳性率更高。干预结束时深部组织阳性的患者中，71%最初在皮肤或皮下组织样本呈阳性。根据针对年龄和性别进行调整的多因素逻辑回归分析，干预开始时皮肤和/或皮下组织样本呈阳性意味着在手术结束时深部组织培养阳性的风险高20倍（p 0.00）。
本研究结果显示痤疮丙酸杆菌的定植率为27%，在年轻男性中发病率更高。
