Pan Tianxin, Trajanovska Misel, Kwong Nathan, King Sebastian K, Goranitis Ilias
Economics of Genomics and Precision Medicine Unit, Centre for Health Policy, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC 3010, Australia.
Murdoch Children's Research Institute, Melbourne, VIC, Australia.
Eur J Health Econ. 2025 Jun 5. doi: 10.1007/s10198-025-01797-0.
To assess the psychometric performance of the Child Health Utility (CHU9D) proxy version compared with the Pediatric Quality of Life Inventory (PedsQL) in Australian children aged 0-7 years with anorectal malformations (ARM) or Hirschsprung disease (HD).
Parents of children with ARM or HD were identified from a patient database managed by a tertiary paediatric hospital in Australia over the past 20 years. Since 2020, CHU9D and PedsQL proxy report versions were administered to parents via telephone interview. Using data collected between 2020 and 2022, we assessed the feasibility, ceiling and floor effects, known-group validity and convergent validity for both instruments in the total sample, by conditions and child age.
The study included 145 children with ARM or HD, among which, 13.1% had missing values on the CHU9D schoolwork dimension, and 20.7% had missing values on the PedsQL school functioning domain (2-4 year old version). The CHU9D and PedsQL did not demonstrate ceiling effects. The CHU9D showed stronger effect size (ES) in differentiating children with ARM (ES = 0.32) or HD (ES = 0.90) with healthy children compared to the PedsQL. We did not find statistically significant differences in CHU9D or PedsQL scores between ARM and HD. There were moderate to strong correlations in most theoretically related dimensions of the CHU9D and PedsQL.
The CHU9D and PedsQL demonstrated comparable and acceptable psychometric properties in Australian children aged 2 years and above with ARM or HD. However, the validity of the CHU9D in children under 2 years old needs to be further explored and modification may be needed.
评估儿童健康效用值（CHU9D）代理版与儿童生活质量量表（PedsQL）在澳大利亚0至7岁患有肛门直肠畸形（ARM）或先天性巨结肠（HD）的儿童中的心理测量性能。
通过澳大利亚一家三级儿科医院管理的患者数据库，识别出过去20年中患有ARM或HD的儿童的父母。自2020年以来，通过电话访谈向父母发放CHU9D和PedsQL代理报告版本。利用2020年至2022年收集的数据，我们按疾病情况和儿童年龄，在总样本中评估了这两种工具的可行性、天花板效应和地板效应、已知组效度和收敛效度。
该研究纳入了145名患有ARM或HD的儿童，其中，13.1%的儿童在CHU9D学业维度上有缺失值，20.7%的儿童在PedsQL学校功能领域（2至4岁版本）有缺失值。CHU9D和PedsQL均未表现出天花板效应。与PedsQL相比，CHU9D在区分患有ARM（效应量=0.32）或HD（效应量=0.90）的儿童与健康儿童方面显示出更强的效应量。我们未发现ARM和HD患儿在CHU9D或PedsQL评分上有统计学显著差异。CHU9D和PedsQL在大多数理论相关维度上存在中度至高度相关性。
CHU9D和PedsQL在澳大利亚2岁及以上患有ARM或HD的儿童中表现出可比且可接受的心理测量特性。然而，CHU9D在2岁以下儿童中的效度需要进一步探索，可能需要进行修改。
