Foux Lorine, Szwarcensztein Karine, Panes Arnaud, Schmidt Aurélie, Herquelot Eléonore, Galvain Thibaut, Phan Thanh Thao Nguyen
Johnson & Johnson Medical SAS, Issy-les-Moulineaux, France.
Heva, Lyon, France.
PLoS One. 2025 Jun 5;20(6):e0324509. doi: 10.1371/journal.pone.0324509. eCollection 2025.
In France, surgical site infections (SSIs) are the second most frequent hospital-acquired infection. The study aimed to estimate the in-hospital clinical and economic burden of SSIs following 4 groups of surgeries. This retrospective observational study was based on the exhaustive national hospital database (PMSI. Adults with ≥1 digestive (colorectal or appendectomy), gynaecologic/obstetric (caesarean section, hysterectomy, or breast), cardiac (artery bypass or aortic valve replacement), or orthopaedic (hip or knee) surgery between 01-01-2019 and 30-11-2020 were included in the study. Patients with SSI were matched with patients without SSI. Patients were followed-up for 30 days except orthopaedic patients (90 days), according to clinical practice. A total of 240675, 331364, 52535, and 407823, patients with digestive, gynaecologic/obstetric, cardiac, and orthopaedic surgery were included. Respectively, 5.8%, 0.1%, 2.0%, and 1.0% of patients experienced an SSI, corresponding to 197.2, 3.4, 68.6, and 11.6 SSIs per 100000 patient-years. SSI patients stayed 13, 7, 15, and 20 extra days at the hospital, costing an extra EUR5246, EUR5363, EUR5725, and EUR11097 (National Health Insurance's perspective). The in-hospital mortality hazard ratios were 2.13, 7.24, 2.90, and 12.01 in SSI patients compared to patients without SSI. SSI greatly increases the risk of death, the length of stay and the hospital cost. Efforts to curtail SSI burden must be renewed.
在法国，手术部位感染（SSIs）是第二常见的医院获得性感染。该研究旨在评估4组手术后手术部位感染的院内临床和经济负担。这项回顾性观察性研究基于详尽的国家医院数据库（PMSI）。纳入了2019年1月1日至2020年11月30日期间接受≥1次消化（结肠直肠或阑尾切除术）、妇科/产科（剖宫产、子宫切除术或乳房手术）、心脏（动脉搭桥或主动脉瓣置换术）或骨科（髋关节或膝关节）手术的成年患者。将手术部位感染患者与未发生手术部位感染的患者进行匹配。根据临床实践，除骨科患者随访90天外，其余患者随访30天。分别纳入了240675例、331364例、52535例和407823例接受消化、妇科/产科、心脏和骨科手术的患者。手术部位感染的患者分别占5.8%、0.1%、2.0%和1.0%，相当于每100000患者年发生197.2例、3.4例、68.6例和11.6例手术部位感染。手术部位感染患者在医院多住院13天、7天、15天和20天，额外费用分别为5246欧元、5363欧元、5725欧元和11097欧元（从国家医疗保险角度）。与未发生手术部位感染的患者相比，手术部位感染患者的院内死亡风险比分别为2.13、7.24、2.90和12.01。手术部位感染大大增加了死亡风险、住院时间和医院费用。必须重新努力减轻手术部位感染的负担。
