Madeira Natália, Campelo Inês, Fonseca Rosalina
Learning and Plasticity, i3s - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Commun Biol. 2025 Jun 5;8(1):873. doi: 10.1038/s42003-025-08289-0.
Memory consolidation is highly influenced by ongoing experiences. Here, we explore the temporal rules that determine whether events are cooperatively associated or competitively separated. We show that neutral events are associated with fearful events if they occur within less than 30 min. In some individuals, memory association can lead to a competitive suppression of the fearful response by the neutral event. Activation of the thalamic MGm inputs to the lateral amygdala, results in an increase in memory association, whereas manipulation of the cortical inputs have no effect. Introducing a third event leads to competition depending on the temporal relationship between the initial association and the competitive event. Our results show a critical temporal rule of memory association, modulated by thalamic activity that shapes fear memory consolidation.
记忆巩固受到当前经历的高度影响。在此，我们探究决定事件是协同关联还是竞争性分离的时间规则。我们发现，如果中性事件在不到30分钟内发生，它们就会与恐惧事件相关联。在一些个体中，记忆关联可导致中性事件对恐惧反应的竞争性抑制。丘脑内侧膝状体向杏仁核外侧的输入激活会导致记忆关联增加，而对皮质输入的操控则没有影响。引入第三个事件会导致竞争，这取决于初始关联事件与竞争事件之间的时间关系。我们的结果显示了记忆关联的关键时间规则，该规则由塑造恐惧记忆巩固的丘脑活动所调节。
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