• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

伏隔核中D1/D2中型多棘神经元在雄性棕色田鼠配偶关系形成中的不同作用

Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles.

作者信息

Zhang Lizi, Qu Yishan, Young Larry J, Hou Wenjuan, Liu Limin, Liu Jing, Wang Yuqian, Li Lu, Guo Xing, Li Yin, Huang Caihong, Lv Zijian, Li Yi-Tong, Jia Rui, Lian Ting, Feng Hao, Qiao Hui, He Zhixiong, Tai Fa-Dao

机构信息

Institute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, China.

Department of Psychiatry and Behavioral Sciences, Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, United States.

出版信息

Elife. 2025 Jun 6;13:RP100292. doi: 10.7554/eLife.100292.

DOI:10.7554/eLife.100292
PMID:40478768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12143883/
Abstract

The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, the involvements of DA release, real-time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (NAc) shell in pair bonding remain unclear. This work verified that male mandarin voles after pair bonding released higher levels of DA in the NAc shell and displayed higher levels of D1 MSNs activity and lower levels of D2 MSNs activity upon sniffing their partners compared to upon sniffing an unknown female. Moreover, pair bonding induced differential alterations in both synaptic plasticity and neuronal intrinsic excitability in both D1 MSNs and D2 MSNs. In addition, chemogenetic inhibition of ventral pallidum (VP) -projecting D2 MSNs in the NAc shell enhanced pair bond formation, while chemogenetic activation of VP-projecting D2 MSNs in the NAc shell inhibited pair bond formation. These findings suggest that different neuronal activity of NAc shell D1 MSNs / D2 MSNs regulated by increasing DA release after pair bonding may be a neurobiological mechanism underlying pair bond formation.

摘要

中脑边缘多巴胺（DA）系统与配偶关系的形成有关。然而，伏隔核（NAc）壳中DA释放、实时活动以及D1/D2中型多棘神经元（MSNs）的电生理活动在配偶关系形成中的作用仍不清楚。这项研究证实，与嗅闻陌生雌性相比，雄性棕色田鼠在建立配偶关系后，嗅闻其配偶时，NAc壳中释放的DA水平更高，D1 MSNs的活动水平更高，D2 MSNs的活动水平更低。此外，配偶关系的形成在D1 MSNs和D2 MSNs的突触可塑性和神经元内在兴奋性方面均引起了不同的变化。此外，化学遗传学抑制NAc壳中投射到腹侧苍白球（VP）的D2 MSNs可增强配偶关系的形成，而化学遗传学激活NAc壳中投射到VP的D2 MSNs则抑制配偶关系的形成。这些发现表明，配偶关系形成后DA释放增加所调节的NAc壳D1 MSNs / D2 MSNs的不同神经元活动可能是配偶关系形成的神经生物学机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/456621f71d55/elife-100292-sa3-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/75fa874f2df7/elife-100292-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/1dd329380023/elife-100292-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/0342a560f7dd/elife-100292-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/961712d0a25e/elife-100292-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/c37d1ed497e5/elife-100292-fig7-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/b4f1056bbad6/elife-100292-fig7-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/9151a2dd04cd/elife-100292-fig7-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/9a382586c02d/elife-100292-sa3-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/456621f71d55/elife-100292-sa3-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/75fa874f2df7/elife-100292-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/1dd329380023/elife-100292-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/0342a560f7dd/elife-100292-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/961712d0a25e/elife-100292-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/c37d1ed497e5/elife-100292-fig7-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/b4f1056bbad6/elife-100292-fig7-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/9151a2dd04cd/elife-100292-fig7-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/9a382586c02d/elife-100292-sa3-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7123/12143883/456621f71d55/elife-100292-sa3-fig2.jpg

相似文献

1
Different roles of D1/D2 medium spiny neurons in the nucleus accumbens in pair bond formation of male mandarin voles.伏隔核中D1/D2中型多棘神经元在雄性棕色田鼠配偶关系形成中的不同作用
Elife. 2025 Jun 6;13:RP100292. doi: 10.7554/eLife.100292.
2
PVN-NAc Shell-VP Circuit OT and OTR Neurons Regulate Pair Bonding via D2R and D1R.室旁核-伏隔核壳部-腹侧苍白球回路中的催产素及催产素受体神经元通过D2R和D1R调节配偶关系。
J Neurosci. 2025 Jun 11;45(24):e2061242025. doi: 10.1523/JNEUROSCI.2061-24.2025.
3
Cocaine induces input and cell-type-specific synaptic plasticity in ventral pallidum-projecting nucleus accumbens medium spiny neurons.可卡因诱导腹侧苍白球投射的伏隔核中中型多棘神经元的输入和细胞类型特异性突触可塑性。
Neuropsychopharmacology. 2022 Jul;47(8):1461-1472. doi: 10.1038/s41386-022-01285-6. Epub 2022 Feb 4.
4
Selective alterations of NMDAR function and plasticity in D1 and D2 medium spiny neurons in the nucleus accumbens shell following chronic intermittent ethanol exposure.慢性间歇性乙醇暴露后伏隔核壳部D1和D2中型多棘神经元中NMDAR功能和可塑性的选择性改变。
Neuropharmacology. 2017 Jan;112(Pt A):164-171. doi: 10.1016/j.neuropharm.2016.03.004. Epub 2016 Mar 2.
5
Excitatory Projections from the Prefrontal Cortex to Nucleus Accumbens Core D1-MSNs and κ Opioid Receptor Modulate Itch-Related Scratching Behaviors.前额叶皮层投射到伏隔核核心 D1-MSNs 的兴奋性投射和 κ 阿片受体调节瘙痒相关抓挠行为。
J Neurosci. 2023 Feb 22;43(8):1334-1347. doi: 10.1523/JNEUROSCI.1359-22.2023. Epub 2023 Jan 18.
6
Suppressive regulation of lateral inhibition between medium spiny neurons via dopamine D receptors in the rat nucleus accumbens shell.大鼠伏隔核壳中多巴胺D受体对中等棘状神经元之间侧向抑制的抑制性调节。
Neurosci Lett. 2017 Jan 1;636:58-63. doi: 10.1016/j.neulet.2016.10.049. Epub 2016 Oct 26.
7
Fundamental Sex Differences in Cocaine-Induced Plasticity of Dopamine D1 Receptor- and D2 Receptor-Expressing Medium Spiny Neurons in the Mouse Nucleus Accumbens Shell.可卡因诱导的小鼠伏隔核壳中表达多巴胺D1受体和D2受体的中等多棘神经元可塑性的基本性别差异。
Biol Psychiatry Glob Open Sci. 2024 Feb 19;4(3):100295. doi: 10.1016/j.bpsgos.2024.100295. eCollection 2024 May.
8
Nucleus accumbens medium spiny neuron subtypes mediate depression-related outcomes to social defeat stress.伏隔核中等多棘神经元亚型介导社会挫败应激相关的抑郁结果。
Biol Psychiatry. 2015 Feb 1;77(3):212-222. doi: 10.1016/j.biopsych.2014.07.021. Epub 2014 Jul 28.
9
Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds.伏隔核多巴胺对一夫一妻制伴侣关系的形成和维持起着不同的调节作用。
Nat Neurosci. 2006 Jan;9(1):133-9. doi: 10.1038/nn1613. Epub 2005 Dec 4.
10
Nucleus accumbens core medium spiny neuron electrophysiological properties and partner preference behavior in the adult male prairie vole, Microtus ochrogaster.成年雄性草原田鼠（Microtus ochrogaster）伏隔核核心中等棘状神经元的电生理特性及伴侣偏好行为
J Neurophysiol. 2018 Apr 1;119(4):1576-1588. doi: 10.1152/jn.00737.2017. Epub 2018 Jan 17.

引用本文的文献

1
PVN-NAc Shell-VP Circuit OT and OTR Neurons Regulate Pair Bonding via D2R and D1R.室旁核-伏隔核壳部-腹侧苍白球回路中的催产素及催产素受体神经元通过D2R和D1R调节配偶关系。
J Neurosci. 2025 Jun 11;45(24):e2061242025. doi: 10.1523/JNEUROSCI.2061-24.2025.

本文引用的文献

1
Nucleus accumbens dopamine release reflects the selective nature of pair bonds.伏隔核多巴胺释放反映了伴侣关系的选择性本质。
Curr Biol. 2024 Feb 5;34(3):519-530.e5. doi: 10.1016/j.cub.2023.12.041. Epub 2024 Jan 12.
2
Disentangling the role of NAc D1 and D2 cells in hedonic eating.解析 NAc D1 和 D2 细胞在享乐性进食中的作用。
Mol Psychiatry. 2023 Aug;28(8):3531-3547. doi: 10.1038/s41380-023-02131-x. Epub 2023 Jul 4.
3
Responses and functions of dopamine in nucleus accumbens core during social behaviors.伏隔核核部中多巴胺的反应和功能在社会行为中的表现。
Cell Rep. 2022 Aug 23;40(8):111246. doi: 10.1016/j.celrep.2022.111246.
4
Cupid's quiver: Integrating sensory cues in rodent mating systems.爱神之箭囊：整合啮齿动物交配系统中的感觉线索。
Front Neural Circuits. 2022 Jul 25;16:944895. doi: 10.3389/fncir.2022.944895. eCollection 2022.
5
Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles.社交经验改变雌性草原田鼠伏隔核内的催产素能调制。
Curr Biol. 2022 Mar 14;32(5):1026-1037.e4. doi: 10.1016/j.cub.2022.01.014. Epub 2022 Feb 1.
6
A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state.一个独特的直接通路中型多棘神经元亚群下调多巴胺以促进负性情绪状态。
Cell Res. 2022 Feb;32(2):139-156. doi: 10.1038/s41422-021-00588-5. Epub 2021 Nov 30.
7
What is a pair bond?什么是配偶关系？
Horm Behav. 2021 Nov;136:105062. doi: 10.1016/j.yhbeh.2021.105062. Epub 2021 Sep 30.
8
Sex-dependent effects of pair bond interruption on anxiety- and depression-like behaviors in adult mandarin voles.伴侣关系中断对成年棕色田鼠焦虑样和抑郁样行为的性别依赖性影响。
Behav Processes. 2021 Nov;192:104497. doi: 10.1016/j.beproc.2021.104497. Epub 2021 Sep 7.
9
Harnessing the healing power of love.利用爱的治愈力量。
Trends Mol Med. 2021 Sep;27(9):833-834. doi: 10.1016/j.molmed.2021.07.010. Epub 2021 Aug 4.
10
Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability.中缝背核至扣带回前部 5-HT 能神经回路调节慰藉和社交性。
Elife. 2021 Jun 3;10:e67638. doi: 10.7554/eLife.67638.