Zhang Lizi, Qu Yishan, Young Larry J, Hou Wenjuan, Liu Limin, Liu Jing, Wang Yuqian, Li Lu, Guo Xing, Li Yin, Huang Caihong, Lv Zijian, Li Yi-Tong, Jia Rui, Lian Ting, Feng Hao, Qiao Hui, He Zhixiong, Tai Fa-Dao
Institute of Brain and Behavioural Sciences, College of Life Sciences, Shaanxi Normal University, Xi'an, China.
Department of Psychiatry and Behavioral Sciences, Silvio O. Conte Center for Oxytocin and Social Cognition, Center for Translational Social Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, United States.
Elife. 2025 Jun 6;13:RP100292. doi: 10.7554/eLife.100292.
The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, the involvements of DA release, real-time activities, and electrophysiological activities of D1/D2 medium spiny neurons (MSNs) in the nucleus accumbens (NAc) shell in pair bonding remain unclear. This work verified that male mandarin voles after pair bonding released higher levels of DA in the NAc shell and displayed higher levels of D1 MSNs activity and lower levels of D2 MSNs activity upon sniffing their partners compared to upon sniffing an unknown female. Moreover, pair bonding induced differential alterations in both synaptic plasticity and neuronal intrinsic excitability in both D1 MSNs and D2 MSNs. In addition, chemogenetic inhibition of ventral pallidum (VP) -projecting D2 MSNs in the NAc shell enhanced pair bond formation, while chemogenetic activation of VP-projecting D2 MSNs in the NAc shell inhibited pair bond formation. These findings suggest that different neuronal activity of NAc shell D1 MSNs / D2 MSNs regulated by increasing DA release after pair bonding may be a neurobiological mechanism underlying pair bond formation.
中脑边缘多巴胺（DA）系统与配偶关系的形成有关。然而，伏隔核（NAc）壳中DA释放、实时活动以及D1/D2中型多棘神经元（MSNs）的电生理活动在配偶关系形成中的作用仍不清楚。这项研究证实，与嗅闻陌生雌性相比，雄性棕色田鼠在建立配偶关系后，嗅闻其配偶时，NAc壳中释放的DA水平更高，D1 MSNs的活动水平更高，D2 MSNs的活动水平更低。此外，配偶关系的形成在D1 MSNs和D2 MSNs的突触可塑性和神经元内在兴奋性方面均引起了不同的变化。此外，化学遗传学抑制NAc壳中投射到腹侧苍白球（VP）的D2 MSNs可增强配偶关系的形成，而化学遗传学激活NAc壳中投射到VP的D2 MSNs则抑制配偶关系的形成。这些发现表明，配偶关系形成后DA释放增加所调节的NAc壳D1 MSNs / D2 MSNs的不同神经元活动可能是配偶关系形成的神经生物学机制。
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