Rajan Akhila, Keene Alex C
Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Biology, Texas A&M university, College Station, TX, USA.
Trends Neurosci. 2025 Jul;48(7):461-463. doi: 10.1016/j.tins.2025.05.011. Epub 2025 Jun 5.
ABC transporters modulate lipid homeostasis and are implicated in neurodegenerative diseases. In a recent study, Chen et al. uncovered unexpected dual roles for the Drosophila ABCA protein eater of debris (Eato), which suppresses phospholipid exposure in both neurons and phagocytes, conferring opposite functional outcomes in each cell type. This challenges classical models of ATP-binding cassette (ABC) transporter function and reveals new mechanisms by which lipid signaling regulates neuron-glia interactions in neurodegenerative contexts.
ABC转运蛋白调节脂质稳态,并与神经退行性疾病有关。在最近的一项研究中,陈等人发现了果蝇ABCA蛋白“碎片吞噬者”(Eato)出人意料的双重作用,它在神经元和吞噬细胞中均抑制磷脂暴露,在每种细胞类型中产生相反的功能结果。这对ATP结合盒(ABC)转运蛋白功能的经典模型提出了挑战,并揭示了脂质信号在神经退行性疾病背景下调节神经元-胶质细胞相互作用的新机制。