Vaccarino F J, Pettit H O, Bloom F E, Koob G F
Pharmacol Biochem Behav. 1985 Sep;23(3):495-8. doi: 10.1016/0091-3057(85)90027-9.
A quaternary derivative of naloxone, methyl naloxonium chloride (MN), was administered intracerebroventricularly (ICV) to rats trained to self-administer heroin intravenously. MN produced a dose-dependent (0.5-4.0 micrograms) increase in responding for heroin. Since MN is unlikely to reach the peripheral circulation in these doses, these results were viewed as strongly supporting the hypothesis that central opiate receptors are solely responsible for mediating the reinforcing properties of heroin during self-administration. In addition, the present study suggests that intracerebral MN injections may prove to be a useful technique in the search for central substrates of heroin reward.
将纳洛酮的一种季铵衍生物，即甲基氯化纳洛酮（MN），经脑室内（ICV）注射给经过训练能静脉自我注射海洛因的大鼠。MN产生了对海洛因反应的剂量依赖性（0.5 - 4.0微克）增加。由于在这些剂量下MN不太可能进入外周循环，这些结果被视为有力支持了以下假设：中枢阿片受体是在自我给药期间介导海洛因强化特性的唯一原因。此外，本研究表明，脑内注射MN可能被证明是寻找海洛因奖赏中枢底物的一种有用技术。
