Slapgaard Laura Vatn, Stafne Signe Nilssen, Rangul Vegar, Dahle Ingrid Aanesland, Horn Julie
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
BMC Pregnancy Childbirth. 2025 Jun 7;25(1):661. doi: 10.1186/s12884-025-07779-7.
Adverse pregnancy outcomes (APOs), including gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), small for gestational age (SGA) offspring, preterm birth and placental abruption, pose significant short and long-term health consequences for mothers and their offspring. Engaging in physical activity may reduce the risk of APOs. We aimed to examine the association between objectively measured physical activity before pregnancy and risk of APOs.
The study population consisted of women with one or more singleton births registered in the Medical Birth Registry of Norway (MBRN) after participating in the fourth survey of the Trøndelag Health Study (HUNT4, 2017-2019). HUNT4 provided data on accelerometer measures on physical activity. We used multivariable adjusted logistic regression models to estimate associations between physical activity (total daily physical activity and metabolic equivalent of task (MET) min/week of moderate to vigorous physical activity (MVPA)) and risk of APOs (GDM, HDP, SGA offspring, preterm birth and/or placental abruption).
Among 700 women included in the study population, 145 (20.7%) experienced at least one APO. Compared to women in the lowest tertile of total physical activity/day, those in the highest tertile had lower odds of GDM (OR 0.19; 95% CI: 0.38-0.93) and potentially lower odds of any APO (OR 0.69; 95% CI: 0.43-1.11). Women with higher levels of total daily physical activity and higher levels of MVPA had lower odds for the composite outcome HDP, GDM, and/or SGA (OR 0.49; 95% CI: 0.28-0.87, highest tertile compared to lowest tertile and OR 0.53; 95% CI: 0.28-1.01, > 1000 MET minutes/week compared to < 500 MET minutes/week).
Increased prepregnancy physical activity, including total daily activity, may reduce the risk APOs. Promoting preconceptional everyday activity could be key to improving pregnancy health. Larger studies are needed to confirm these findings.
不良妊娠结局（APO），包括妊娠期糖尿病（GDM）、妊娠高血压疾病（HDP）、小于胎龄儿（SGA）、早产和胎盘早剥，会对母亲及其后代造成重大的短期和长期健康影响。进行体育活动可能会降低发生APO的风险。我们旨在研究孕前客观测量的体育活动与APO风险之间的关联。
研究人群包括参与特隆赫姆健康研究第四次调查（HUNT4，2017 - 2019年）后在挪威医疗出生登记处（MBRN）登记有一次或多次单胎分娩的女性。HUNT4提供了关于体育活动的加速度计测量数据。我们使用多变量调整逻辑回归模型来估计体育活动（每日总体育活动量和中度至剧烈体育活动（MVPA）的代谢当量任务（MET）分钟/周）与APO风险（GDM、HDP、SGA后代、早产和/或胎盘早剥）之间的关联。
在纳入研究人群的700名女性中，145名（20.7%）经历了至少一种APO。与每日总体育活动量处于最低三分位数的女性相比，最高三分位数的女性患GDM的几率较低（OR 0.19；95% CI：0.38 - 0.93），发生任何APO的几率可能也较低（OR 0.69；95% CI：0.43 - 1.11）。每日总体育活动量较高且MVPA水平较高的女性发生HDP、GDM和/或SGA综合结局的几率较低（OR 0.49；95% CI：0.28 - 0.87，最高三分位数与最低三分位数相比；OR 0.53；95% CI：0.28 - 1.01，每周>1000 MET分钟与每周<50 MET分钟相比）。
孕前体育活动增加，包括每日总活动量，可能会降低APO的风险。促进孕前日常活动可能是改善妊娠健康的关键。需要更大规模的研究来证实这些发现。
