Liu Fangli, Lv Jingjing, Chen Yuanyuan, Wang Linfeng, Liu Zhuoxin, Li Xingke
School of Nursing and Health, Henan University, Kaifeng, 475004, China.
College of Life Sciences Institute of Biological Engineering, Henan University, Kaifeng, 475004, China.
Nutr Metab (Lond). 2025 Jun 7;22(1):56. doi: 10.1186/s12986-025-00954-9.
The incidence and prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver disease characterized by hepatic steatosis without substantial alcohol consumption, are rapidly increasing worldwide. Liver cirrhosis and cancer are relatively common in MASLD patients. Therefore, it is essential to take proactive measures in preventing its onset or initiating prompt treatment. However, there is a lack of approved medications for effectively treating this ailment. Lipoic acid (LA), a compound with antioxidant, insulin-sensitization, anti-inflammatory, and prooxidant activities, has been proven to inhibit lipid deposition. Many studies have shown that supplementation of LA can alleviate MASLD. Therefore, the latest evidence on the relationship between LA and MASLD is presented in this review. The effect of LA on the accumulation of fat in the liver is emphasized following different diet models (normal, high fat, high fructose, choline deficiency) and other models (gene mutation, diabetes), with the main mechanisms from mitochondrial function to inflammation and oxidative stress being summarized. LA possesses excellent preventive effects on MASLD, which can provide new opportunities for clinical research.
代谢功能障碍相关脂肪性肝病（MASLD）是一种以无大量饮酒情况下的肝脂肪变性为特征的慢性肝病，其发病率和患病率在全球范围内正在迅速上升。肝硬化和癌症在MASLD患者中相对常见。因此，采取积极措施预防其发病或尽早开始治疗至关重要。然而，目前缺乏有效治疗这种疾病的获批药物。硫辛酸（LA）是一种具有抗氧化、胰岛素增敏、抗炎和促氧化活性的化合物，已被证明能抑制脂质沉积。许多研究表明，补充LA可以缓解MASLD。因此，本综述介绍了关于LA与MASLD关系的最新证据。在不同饮食模式（正常、高脂肪、高果糖、胆碱缺乏）和其他模式（基因突变、糖尿病）下，强调了LA对肝脏脂肪积累的影响，并总结了从线粒体功能到炎症和氧化应激的主要机制。LA对MASLD具有出色的预防作用，可为临床研究提供新的机会。
